Evidence map›Paper›PMID 34884748›Full record

ArticleInternational journal of molecular sciences2021

Lentiviral-Induced Spinal Cord Gliomas in Rat Model.

Purva P Nagarajan, Muhibullah S Tora, Stewart G Neill, Thais Federici, Pavlos Texakalidis, Anthony Donsante, Peter Canoll, Kecheng Lei, Nicholas M Boulis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Purva P NagarajanDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Muhibullah S ToraDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Stewart G NeillDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Thais FedericiDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Pavlos TexakalidisDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Anthony DonsanteDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Peter CanollDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Kecheng LeiDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-2607-8960
Nicholas M BoulisDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory University · USGeorgia Institute of Technology · USColumbia University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Supplement: Lentiviral-Induced Swine Model of Spinal Cord Glioma - Tumor Microenvironment in IDH-Mutations Low-Grade GliomaR01CA251393 · NCI · EMORY UNIVERSITY · PI BOULIS, NICHOLAS M, CANOLL, PETER · 2021 to 2025
$2.9M
Targeting Go and Grow in GlioblastomaR01NS118513 · NINDS · MAYO CLINIC JACKSONVILLE · PI CANOLL, PETER, KENCHAPPA, RAJAPPA · 2020 to 2024
$2.8M
NCI NIH HHS R01 CA251393NCI NIH HHS R01CA251393NIGMS NIH HHS T32 GM008169NINDS NIH HHS R01 NS118513
6 · The paper itself

Abstract

Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords of minipigs. In this study, we evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas. Eight groups of rats (

Indexed as

AnimalsBiomarkers, TumorCell ProliferationGenetic VectorsGliomaLentivirusMutationNeoplasms, ExperimentalOncogene ProteinsPlatelet-Derived Growth Factorras ProteinsRatsRats, Sprague-DawleyRNA, Small InterferingSpinal Cord NeoplasmsTumor Suppressor Protein p53Biomarkers, TumorHras protein, ratOncogene ProteinsPlatelet-Derived Growth Factorras ProteinsRNA, Small InterferingTp53 protein, ratTumor Suppressor Protein p53HRASlentivirusP53PDGF-Brat modelspinal cord glioma

Identifiers

PMID34884748
PMCPMC8657985
OpenAlexW3217241085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.