Evidence map›Paper›PMID 34884723›Full record

ArticleInternational journal of molecular sciences2021

Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML.

Franziska Brauneck, Elisa Seubert, Jasmin Wellbrock, Julian Schulze Zur Wiesch, Yinghui Duan, Tim Magnus, Carsten Bokemeyer, Friedrich Koch-Nolte, Stephan Menzel, Walter Fiedler

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Neoantigen mRNA vaccines and AHuman vaccines & immunotherapeutics · 2025
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  7. Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Review
  8. Article
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  10. Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment.International journal of molecular sciences · 2024
    Review
  11. Murine Regulatory CD4International journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. [ARL67156, a small-molecule CD39 inhibitor, enhances natural killer cell cytotoxicity against gastric cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  19. CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells.International journal of molecular sciences · 2023
    Article
  20. The Immune Regulatory Role of Adenosine in the Tumor Microenvironment.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Franziska BrauneckDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Elisa SeubertDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-0013-0270
Jasmin WellbrockDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Julian Schulze Zur WieschInfectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-5033-1938
Yinghui DuanDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Tim MagnusDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Carsten BokemeyerDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0001-6071-7810
Friedrich Koch-NolteInstitute of Immunology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-1730-6674
Stephan MenzelMildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Walter FiedlerDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-0275-8803
Universität Hamburg · DE

Funding

E. S. was supported by the E.W. Kuhlmann StiftungF.B. and S.M. were supported by the MSNZ, University Medical Center Hamburg-EppendorfF. K.-N. was supported by the DFG SFB1328 (project Z02)J. S.z.W. was supported by the DFG SFB841 project A6
6 · The paper itself

Abstract

This study aimed to characterize different natural killer (NK) cell phenotypes on bone marrow and peripheral blood cells from acute myeloid leukemia (AML) patients and healthy donors (HDs). Our data show that CD56

Indexed as

AdultAgedAged, 80 and overApyraseCase-Control StudiesHumansImmunotherapyKiller Cells, NaturalLeukemia, Myeloid, AcuteMiddle AgedReceptor, Adenosine A2AReceptors, ImmunologicYoung AdultADORA2A protein, humanApyraseENTPD1 protein, humanReceptor, Adenosine A2AReceptors, ImmunologicTIGIT protein, humanAMLcombined blockade of TIGIT and CD39 or A2ARNK cell-mediated cytotoxicityNK cells

Identifiers

PMID34884723
PMCPMC8657570
OpenAlexW3216661796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.