Evidence map›Paper›PMID 34884715›Full record

ArticleInternational journal of molecular sciences2021

Investigation of the Characteristics and Antibacterial Activity of Polymer-Modified Copper Oxide Nanoparticles.

Nan-Fu Chen, Yu-Hsiang Liao, Pei-Ying Lin, Wu-Fu Chen, Zhi-Hong Wen, Shuchen Hsieh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 45 citations in OpenAlex.

  1. Chitosan-Loaded Inorganic Oxide Nanocomposites (SiOFoods (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Antibacterial Properties of Copper Oxide Nanoparticles (Review).International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Nan-Fu ChenDivision of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Yu-Hsiang LiaoDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Pei-Ying LinDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Wu-Fu ChenDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833301, Taiwan.
Zhi-Hong WenDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.ORCID 0000-0003-4411-044X
Shuchen HsiehDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
National Sun Yat-sen University · TW

Funding

Kaohsiung Armed Forces General HospitalMinistry of Science and Technology MOST 109-2113-M-110-001 and 110-2113-M-110-018National Sun Yat-sen UniversityRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University
6 · The paper itself

Abstract

The proliferation of drug-resistant pathogens continues to increase, giving rise to serious public health concerns. Many researchers have formulated metal oxide nanoparticles for use as novel antibacterial agents. In the present study, copper oxide (CuO) was synthesized by simple hydrothermal synthesis, and doping was performed to introduce different polymers onto the NP surface for bacteriostasis optimization. The polymer-modified CuO NPs were analyzed further with XRD, FTIR, TEM, DLS and zeta potential to study their morphology, size, and the charge of the substrate. The results indicate that polymer-modified CuO NPs had a significantly higher bacteriostatic rate than unmodified CuO NPs. In particular, polydopamine (PDA)-modified CuO (CuO-PDA) NPs, which carry a weakly negative surface charge, exhibited excellent antibacterial effects, with a bacteriostatic rate of up to 85.8 ± 0.2% within 3 h. When compared to other polymer-modified CuO NPs, CuO-PDA NPs exhibited superior bacteriostatic activity due to their smaller size, surface charge, and favorable van der Waals interactions. This may be attributed to the fact that the CuO-PDA NPs had relatively lipophilic structures at pH 7.4, which increased their affinity for the lipopolysaccharide-containing outer membrane of the Gram-negative bacterium

Indexed as

Anti-Bacterial AgentsCopperMetal NanoparticlesMicrobial Sensitivity TestsAnti-Bacterial AgentsCoppercupric oxideantibacterial agentsbiocompatibilitycopper oxidenanoparticlespolymer

Identifiers

PMID34884715
PMCPMC8658000
OpenAlexW3214941405

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.