Evidence map›Paper›PMID 34884710›Full record

ArticleInternational journal of molecular sciences2021

The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.

Justyna M Wierzbicka, Anna Piotrowska, Dorota Purzycka-Bohdan, Anna Olszewska, Joanna I Nowak, Aneta Szczerkowska-Dobosz, Bogusław Nedoszytko, Roman J Nowicki, Michał A Żmijewski

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. 1,24,25(OH)Scientific reports · 2025
    Article
  2. IL-31/33 Axis in Atopic Dermatitis.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. An ALARMINg Type 2 Response in Cystic Fibrosis-The Key to Understanding ABPA?American journal of respiratory and critical care medicine · 2023
    Article
  10. New Insights into Psoriasis.International journal of molecular sciences · 2022
    Article
  11. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Justyna M WierzbickaHistology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0001-6109-0685
Anna PiotrowskaHistology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0002-2672-0474
Dorota Purzycka-BohdanDepartment of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.ORCID 0000-0002-6089-8030
Anna OlszewskaHistology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
Joanna I NowakHistology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
Aneta Szczerkowska-DoboszDepartment of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
Bogusław NedoszytkoDepartment of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
Roman J NowickiDepartment of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.ORCID 0000-0003-4768-1387
Michał A ŻmijewskiHistology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0003-2206-3531
Gdańsk Medical University · PL

Funding

Narodowe Centrum Nauki 2017/25/B/NZ3/00431
6 · The paper itself

Abstract

Interleukin 33 (IL-33) belongs to the IL-1 family and is produced constitutively by epithelial and endothelial cells of various organs, such as the skin. It takes part in the maintenance of tissue homeostasis, repair, and immune response, including activation of Th2 lymphocytes. Its involvement in pathogenesis of several inflammatory diseases including psoriasis was also suggested, but this is not fully understood. The aim of the study was to investigate expression of IL-33 and its receptor, ST2, in psoriasis, and the effects of the active form of vitamin D (1,25(OH)

Indexed as

AdolescentCase-Control StudiesHumansInterleukin-1 Receptor-Like 1 ProteinInterleukin-33KeratinocytesPsoriasisSkinVitamin DVitaminsIL1RL1 protein, humanIL33 protein, humanInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Vitamin DVitaminsIL-33psoriasisskinST2vitamin D

Identifiers

PMID34884710
PMCPMC8657669
OpenAlexW3217284090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.