Evidence map›Paper›PMID 34884681›Full record

ArticleInternational journal of molecular sciences2021

Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation.

Barbara Meier-Schiesser, Mark Mellett, Marigdalia K Ramirez-Fort, Julia-Tatjana Maul, Annika Klug, Nicola Winkelbeiner, Gabriele Fenini, Peter Schafer, Emmanuel Contassot, Lars E French

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Barbara Meier-SchiesserDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.ORCID 0000-0003-2807-5066
Mark MellettDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.ORCID 0000-0002-6315-167X
Marigdalia K Ramirez-FortBioFort, P.O. Box 1374, Guaynabo, PR 00970, USA.
Julia-Tatjana MaulDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Annika KlugDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Nicola WinkelbeinerDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.
Gabriele FeniniDepartment of Dermatology, University Hospital Zurich (USZ), Raemistrasse 100, 8091 Zurich, Switzerland.ORCID 0000-0002-5778-936X
Peter SchaferBristol Myers Squibb, 100 Nassau Park Blvd #300, Princeton, NJ 08540, USA.
Emmanuel ContassotDepartment of Biomedicine, Dermatology Department, Basel University Hospital, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Lars E FrenchDepartment of Dermatology, Ludwigs-Maximilians-University, Frauenlobstraße 9-11, 80337 Munich, Germany.
University Hospital of Zurich · CHBristol-Myers Squibb (United States) · USUniversity of Basel · CHUniversity of Miami · US

Funding

Celgene 0
6 · The paper itself

Abstract

Apremilast (Otezla

Indexed as

AnimalsDrug Evaluation, PreclinicalHumansImmunity, InnateInflammasomesInterleukin-1betaMice, TransgenicPhosphodiesterase 4 InhibitorsPsoriasisThalidomideapremilastIL1B protein, mouseInflammasomesInterleukin-1betaPhosphodiesterase 4 InhibitorsThalidomidecytokinesinflammasomePDE4 inhibition

Identifiers

PMID34884681
PMCPMC8657753
OpenAlexW3216574708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.