Evidence map›Paper›PMID 34884653›Full record

ArticleInternational journal of molecular sciences2021

The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor.

Maria Laura de Souza Lima, Agnes Andrade Martins, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernardo Guerra, Robson Santos, Michael Bader, Flavia Q Pirih, Raimundo Fernandes de Araújo Júnior, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Maria Laura de Souza LimaPostgraduate Program in Dentistry Sciences, Department of Biophysical and Pharmacology, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Agnes Andrade MartinsDepartment of Dentistry, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Caroline Addison Carvalho Xavier de MedeirosPostgraduate Program in Biochemistry and Molecular Biology, Postgraduate Program in RENORBIO, Department of Biophysical and Pharmacology, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.ORCID 0000-0001-9224-2434
Gerlane Coelho Bernardo GuerraPostgraduate Program in Biochemistry and Molecular Biology, Postgraduate Program in Pharmaceutical Science, Department of Biophysical and Pharmacology, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Robson SantosDepartment of Physiology, Federal University of Minas Gerais, Belo Horizonte CEP 31270-901, MG, Brazil.ORCID 0000-0001-8738-5852
Michael BaderMax Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Flavia Q PirihSchool of Dentistry, University of California-Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Raimundo Fernandes de Araújo JúniorPostgraduate Program in Health Sciences, Postgraduate Program in Functional and Structural Biology UFRN, Department of Morphology, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Gerly Anne de Castro BritoPostgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza CEP 60430-170, CE, Brazil.
Renata Ferreira de Carvalho LeitãoPostgraduate Program in Morphology, Department of Morphology, Federal University of Ceará, Fortaleza CEP 60430-170, CE, Brazil.ORCID 0000-0003-0202-771X
Rafaela Alcindo SilvaPostgraduate Program in Dentistry Sciences, Department of Dentistry, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Stphannie Jamyla de Araújo BarbosaPostgraduate Program in Pharmaceutical Science, Department of Pharmaceutical Science, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Rômulo Camilo de Oliveira MeloDiscipline of Radiology, Department of Dentistry, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.
Aurigena Antunes de AraújoVisiting Research in UCLA, Postgraduate Program in Dentistry Sciences, Postgraduate Program in Pharmaceutical Sciences, Department of Biophysical and Pharmacology, Federal University of Rio Grande Norte, Natal CEP 59072-970, RN, Brazil.ORCID 0000-0001-9264-4695
Universidade Federal do Rio Grande do Norte · BRUniversidade Federal do Ceará · BRMax Delbrück Center · DEUniversidade Federal de Minas Gerais · BRUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on periodontitis.

Indexed as

Alveolar Bone LossAngiotensin IIAnimalsDisease Models, AnimalMaleMandibular DiseasesMiceMice, KnockoutPeriodontitisReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Angiotensin IIReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2bonemicro-computed tomographymolecularperiodontal disease

Identifiers

PMID34884653
PMCPMC8657877
OpenAlexW3216089810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.