Evidence map›Paper›PMID 34884635›Full record

ReviewInternational journal of molecular sciences2021

A Dynamic Network of Proteins Facilitate Cell Envelope Biogenesis in Gram-Negative Bacteria.

Chris L B Graham, Hector Newman, Francesca N Gillett, Katie Smart, Nicholas Briggs, Manuel Banzhaf, David I Roper

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Species-Specific Stress Responses to Selenium Nanoparticles inNanomaterials (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Journal of bacteriology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Cpx-signalling innpj antimicrobials and resistance · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Plasticity in the cell division processes of obligate intracellular bacteria.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Non-typeableFrontiers in cellular and infection microbiology · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chris L B GrahamSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
Hector NewmanSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
Francesca N GillettSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
Katie SmartSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0003-1748-661X
Nicholas BriggsSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
Manuel BanzhafSchool of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
David I RoperSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0003-0009-621X
University of Warwick · GBUniversity of Birmingham · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M01116X/1Diamond Light Source STU0212Medical Research Council MR/J003964/1
6 · The paper itself

Abstract

Bacteria must maintain the ability to modify and repair the peptidoglycan layer without jeopardising its essential functions in cell shape, cellular integrity and intermolecular interactions. A range of new experimental techniques is bringing an advanced understanding of how bacteria regulate and achieve peptidoglycan synthesis, particularly in respect of the central role played by complexes of Sporulation, Elongation or Division (SEDs) and class B penicillin-binding proteins required for cell division, growth and shape. In this review we highlight relationships implicated by a bioinformatic approach between the outer membrane, cytoskeletal components, periplasmic control proteins, and cell elongation/division proteins to provide further perspective on the interactions of these cell division, growth and shape complexes. We detail the network of protein interactions that assist in the formation of peptidoglycan and highlight the increasingly dynamic and connected set of protein machinery and macrostructures that assist in creating the cell envelope layers in Gram-negative bacteria.

Indexed as

Bacterial ProteinsCell MembraneCell WallGram-Negative BacteriaPenicillin-Binding ProteinsPeptidoglycanPeriplasmic ProteinsBacterial ProteinsPenicillin-Binding ProteinsPeptidoglycanPeriplasmic Proteinscell divisioncomplexescytoskeletondynamicenvelopeEscherichia coligram-negativeinteractionsnetworkouter membranepeptidoglycanprotein-proteinseds

Identifiers

PMID34884635
PMCPMC8657477
OpenAlexW3217413035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.