Evidence map›Paper›PMID 34884631›Full record

ArticleInternational journal of molecular sciences2021

Towards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues.

Anna Empel, Andrzej Bak, Violetta Kozik, Malgorzata Latocha, Alois Cizek, Josef Jampilek, Kinga Suwinska, Aleksander Sochanik, Andrzej Zieba

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Design, Spectral Insights, and Enhanced Antioxidant Potential of Novel Phenothiazine DerivativesAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Chemistry towards Biology.International journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Chemistry towards Biology-Instruct: Snapshot.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna EmpelDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Andrzej BakInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.ORCID 0000-0002-9842-1289
Violetta KozikInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.
Malgorzata LatochaDepartment of Cell Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 9, 41-200 Sosnowiec, Poland.
Alois CizekDepartment of Infectious Diseases and Microbiology, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Palackeho 1946/1, 61242 Brno, Czech Republic.ORCID 0000-0001-5706-4601
Josef JampilekDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, Slovakia.ORCID 0000-0003-2003-9052
Kinga SuwinskaFaculty of Mathematics and Natural Sciences, Cardinal Stefan Wyszyński University, K. Woycickiego 1/3, 01-938 Warszawa, Poland.ORCID 0000-0002-6702-0773
Aleksander SochanikCenter for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Wybrzeże AK 15, 44-101 Gliwice, Poland.
Andrzej ZiebaDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsHeterocyclic CompoundsHumansMicrobial Sensitivity TestsNeoplasmsPhenothiazinesStaphylococcus aureusStructure-Activity RelationshipTumor Cells, CulturedAnti-Bacterial AgentsAntineoplastic AgentsHeterocyclic CompoundsPhenothiazinesantibacterial activityantiproliferative activityazaphenothiazineslipophilicitypharmacophore mappingphenothiazinesimilarity-activity landscape index

Identifiers

PMID34884631
PMCPMC8658022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.