Evidence map›Paper›PMID 34884627›Full record

ReviewInternational journal of molecular sciences2021

The Flavonoid Biosynthesis Network in Plants.

Weixin Liu, Yi Feng, Suhang Yu, Zhengqi Fan, Xinlei Li, Jiyuan Li, Hengfu Yin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 419 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
419citing papers in PubMed, 1 pooled it
42.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

419 citing papers in PubMed, 1 synthesis or guideline pooled it, 888 citations in OpenAlex.

  1. Pooled it
  2. Functional analysis ofPlant signaling & behavior · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. TheHorticulture research · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. PlantInternational journal of molecular sciences · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Article

359 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Weixin LiuState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.ORCID 0000-0002-2076-3342
Yi FengState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Suhang YuState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Zhengqi FanState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Xinlei LiState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Jiyuan LiState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.
Hengfu YinState Key Laboratory of Tree Genetics and Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China.ORCID 0000-0002-0720-5311
Chinese Academy of Forestry · CN

Funding

National Key R&D Program of China 2019YFD1000Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding 2021C02071-2
6 · The paper itself

Abstract

Flavonoids are an important class of secondary metabolites widely found in plants, contributing to plant growth and development and having prominent applications in food and medicine. The biosynthesis of flavonoids has long been the focus of intense research in plant biology. Flavonoids are derived from the phenylpropanoid metabolic pathway, and have a basic structure that comprises a C15 benzene ring structure of C6-C3-C6. Over recent decades, a considerable number of studies have been directed at elucidating the mechanisms involved in flavonoid biosynthesis in plants. In this review, we systematically summarize the flavonoid biosynthetic pathway. We further assemble an exhaustive map of flavonoid biosynthesis in plants comprising eight branches (stilbene, aurone, flavone, isoflavone, flavonol, phlobaphene, proanthocyanidin, and anthocyanin biosynthesis) and four important intermediate metabolites (chalcone, flavanone, dihydroflavonol, and leucoanthocyanidin). This review affords a comprehensive overview of the current knowledge regarding flavonoid biosynthesis, and provides the theoretical basis for further elucidating the pathways involved in the biosynthesis of flavonoids, which will aid in better understanding their functions and potential uses.

Indexed as

Biosynthetic PathwaysGene Expression Regulation, PlantGene Regulatory NetworksFlavonoidsPlant ProteinsPlantsFlavonoidsPlant Proteinsbiosynthesisbiosynthetic enzymeflavonoidsgene regulationmolecular structure

Identifiers

PMID34884627
PMCPMC8657439
OpenAlexW3216174003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.