ArticleInternational journal of molecular sciences2021
Erythrocytes Prevent Degradation of Carnosine by Human Serum Carnosinase.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Construction of EngineeredBiomolecules · 2026Article
- The Effect of Serum Carnosinase on the Tissue Distribution of Imidazole Dipeptides After Their Oral Administration in Golden Hamsters.Nutrients · 2026Article
- Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study.Amino acids · 2025Review
- Histidine-Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Article
- Preworkout Consumption of Chicken Essence Elicits Post-Exercise Hypotension in Prehypertensive Offspring of Hypertensive Parents: A Crossover Randomized Controlled Trial.Preventive nutrition and food science · 2024Article
- Special Issue "Peptides for Health Benefits 2021".International journal of molecular sciences · 2024Article
- Comparative evaluation of different modalities for measuring in vivo carnosine levels.PloS one · 2024Article
- Article
- Article
- Anserine and Carnosine Induce HSP70-Dependent HAntioxidants (Basel, Switzerland) · 2022Article
- Quantitation of non-derivatized free amino acids for detecting inborn errors of metabolism by incorporating mixed-mode chromatography with tandem mass spectrometry.Journal of mass spectrometry and advances in the clinical lab · 2022Article
- Viability of Glioblastoma Cells and Fibroblasts in the Presence of Imidazole-Containing Compounds.International journal of molecular sciences · 2022Article
- Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper.Molecules (Basel, Switzerland) · 2022Review
- Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme.ACS chemical neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The naturally occurring dipeptide carnosine (β-alanyl-l-histidine) has beneficial effects in different diseases. It is also frequently used as a food supplement to improve exercise performance and because of its anti-aging effects. Nevertheless, after oral ingestion, the dipeptide is not detectable in human serum because of rapid degradation by serum carnosinase. At the same time, intact carnosine is excreted in urine up to five hours after intake. Therefore, an unknown compartment protecting the dipeptide from degradation has long been hypothesized. Considering that erythrocytes may constitute this compartment, we investigated the uptake and intracellular amounts of carnosine in human erythrocytes cultivated in the presence of the dipeptide and human serum using liquid chromatography-mass spectrometry. In addition, we studied carnosine's effect on ATP production in red blood cells and on their response to oxidative stress. Our experiments revealed uptake of carnosine into erythrocytes and protection from carnosinase degradation. In addition, no negative effect on ATP production or defense against oxidative stress was observed. In conclusion, our results for the first time demonstrate that erythrocytes can take up carnosine, and, most importantly, thereby prevent its degradation by human serum carnosinase.
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