Evidence map›Paper›PMID 34884538›Full record

ArticleInternational journal of molecular sciences2021

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis.

John E La Marca, Lee F Willoughby, Kirsten Allan, Marta Portela, Pei Kee Goh, Tony Tiganis, Helena E Richardson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

John E La MarcaCell Polarity, Cell Signaling & Cancer Laboratory, Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0001-6442-9947
Lee F WilloughbyCell Cycle & Development Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia.
Kirsten AllanCell Polarity, Cell Signaling & Cancer Laboratory, Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Marta PortelaCell Polarity, Cell Signaling & Cancer Laboratory, Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0001-7898-962X
Pei Kee GohMonash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Tony TiganisMonash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Helena E RichardsonCell Polarity, Cell Signaling & Cancer Laboratory, Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0003-3852-4953
La Trobe University · AUAustralian Regenerative Medicine Institute · AUPeter MacCallum Cancer Centre · AUThe University of Melbourne · AU

Funding

Australian Research Council DP170102549Australian Research Council DPP120103943Cancer Council Victoria APP1041817National Health and Medical Research Council APP1020056National Health and Medical Research Council APP1103037
6 · The paper itself

Abstract

Tissue homeostasis via the elimination of aberrant cells is fundamental for organism survival. Cell competition is a key homeostatic mechanism, contributing to the recognition and elimination of aberrant cells, preventing their malignant progression and the development of tumors. Here, using

Indexed as

Cell CompetitionAnimalsCarcinogenesisDrosophila melanogasterDrosophila ProteinsJanus Kinase 1Mitogen-Activated Protein Kinase KinasesNeoplasmsProtein Tyrosine Phosphatases, Non-Receptorras ProteinsSignal TransductionSTAT Transcription FactorsDrosophila ProteinsJanus Kinase 1Mitogen-Activated Protein Kinase KinasesProtein Tyrosine Phosphatases, Non-ReceptorPtp61F protein, Drosophilaras ProteinsSTAT Transcription Factorscell competitionJAK–STATPTP61FRAStumorigenesis

Identifiers

PMID34884538
PMCPMC8657627
OpenAlexW3215601884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.