Evidence map›Paper›PMID 34884508›Full record

ArticleInternational journal of molecular sciences2021

GRPEL2 Knockdown Exerts Redox Regulation in Glioblastoma.

Chi-Tun Tang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Shih-Ming Huang, Dueng-Yuan Hueng, Chia-Kuang Tsai, Yuan-Hao Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Proteolytic control of mitochondrial protein translocases.Protein science : a publication of the Protein Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chi-Tun TangDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0003-3805-0348
Yao-Feng LiDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Chung-Hsing ChouGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-9584-0843
Li-Chun HuangDepartment of Biochemistry, National Defense Medical Center, Taipei 11490, Taiwan.
Shih-Ming HuangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-9305-921X
Dueng-Yuan HuengDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-7868-3161
Chia-Kuang TsaiGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0001-7693-1408
Yuan-Hao ChenDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-0570-4328
Tri-Service General Hospital · TWNational Defense Medical Center · TW

Funding

Ministry of National Defense Medical Affairs Bureau MAB-108-064 (C.-K.T.)Ministry of Science and Technology MOST-110- 2314-B-016-035 (C.-K.T.)Tri-Service General Hospital, Taipei TSGH-E-110195 (C.-K.T.); TSGH-C-108097 (C.-T.T.)
6 · The paper itself

Abstract

Malignant brain tumors are responsible for catastrophic morbidity and mortality globally. Among them, glioblastoma multiforme (GBM) bears the worst prognosis. The GrpE-like 2 homolog (

Indexed as

Gene Expression Regulation, NeoplasticApoptosisBrain NeoplasmsCase-Control StudiesCell CycleCell ProliferationGlioblastomaHumansIntracellular Signaling Peptides and ProteinsMembrane Potential, MitochondrialMitochondriaOxidation-ReductionPrognosisProtein TransportReactive Oxygen SpeciesSurvival RateGRPEL2 protein, humanIntracellular Signaling Peptides and ProteinsReactive Oxygen SpeciesautophagyglioblastomaGrpE-like 2 homolog (GRPEL2)oxygen consumption rate (OCR)senescence

Identifiers

PMID34884508
PMCPMC8657957
OpenAlexW3215735169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.