Evidence map›Paper›PMID 34884497›Full record

ArticleInternational journal of molecular sciences2021

Mutations That Affect the Surface Expression of TRPV6 Are Associated with the Upregulation of Serine Proteases in the Placenta of an Infant.

Claudia Fecher-Trost, Karin Wolske, Christine Wesely, Heidi Löhr, Daniel S Klawitter, Petra Weissgerber, Elise Gradhand, Christine P Burren, Anna E Mason, Manuel Winter and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  4. Placental Related Disorders of Pregnancy.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Claudia Fecher-TrostExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Karin WolskeExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Christine WeselyExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Heidi LöhrExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Daniel S KlawitterExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Petra WeissgerberExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.ORCID 0000-0003-3770-3749
Elise GradhandKinder- und Perinatalpathologie Dr. Senckenberg, Institut für Pathologie Universitätsklinikum Frankfurt/Main Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Christine P BurrenDepartment of Translational Health Sciences, Bristol Medical School, University of Bristol, University Hospitals Bristol and Weston NHS Foundation Trust, Upper Maudlin St, Bristol BS2 8BJ, UK.
Anna E MasonHistopathology Department, Aneurin Bevan University Health Board, Royal Gwent Hospital, Cardiff NP20 2UB, UK.ORCID 0000-0001-7920-8186
Manuel WinterExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Ulrich WissenbachExperimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 61.4 and 46, 66421 Homburg, Germany.
Saarland University · DEGoethe University Frankfurt · DERoyal Gwent Hospital · GBUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

Deutsche Forschungsgemeinschaft FE629/2 WE4866/1- 1 SFB894/P2
6 · The paper itself

Abstract

Recently, we reported a case of an infant with neonatal severe under-mineralizing skeletal dysplasia caused by mutations within both alleles of the

Indexed as

MutationAmino Acid SequenceAnimalsCalcium ChannelsCase-Control StudiesCathepsin GFemaleGene Expression Regulation, EnzymologicHigh-Temperature Requirement A Serine Peptidase 1HumansInfantMiceMice, KnockoutOsteochondrodysplasiasPlacentaPregnancyCalcium ChannelsCathepsin GCTSG protein, humanHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanProteomeTRPV6 protein, humanTrpv6 protein, mouseTRPV Cation Channelscalcium transportplacentaserine proteasesskeletal dysplasiasubunit assemblytransient receptor potentialTRPV6

Identifiers

PMID34884497
PMCPMC8657554
OpenAlexW3215169860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.