Evidence map›Paper›PMID 34884467›Full record

ReviewInternational journal of molecular sciences2021

Self-Assembling Peptides: From Design to Biomedical Applications.

Sara La Manna, Concetta Di Natale, Valentina Onesto, Daniela Marasco

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 105 citations in OpenAlex.

  1. Review
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  4. RBM45 Preferential Binding to mThe journal of physical chemistry. B · 2026
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  5. Review
  6. Review
  7. Review
  8. Article
  9. Engineering Bispecific Peptides for Precision Immunotherapy and Beyond.International journal of molecular sciences · 2025
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sara La MannaDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7762-0708
Concetta Di NataleIstituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci, 53, 80125 Napoli, Italy.
Valentina OnestoInstitute of Nanotechnology, Consiglio Nazionale delle Ricerche, CNR NANOTEC, via Monteroni, c/o Campus Ecotekne, 73100 Lecce, Italy.ORCID 0000-0002-2308-4126
Daniela MarascoDepartment of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-6618-2949
University of Naples Federico II · ITIstituto di Nanotecnologia · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling peptides could be considered a novel class of agents able to harvest an array of micro/nanostructures that are highly attractive in the biomedical field. By modifying their amino acid composition, it is possible to mime several biological functions; when assembled in micro/nanostructures, they can be used for a variety of purposes such as tissue regeneration and engineering or drug delivery to improve drug release and/or stability and to reduce side effects. Other significant advantages of self-assembled peptides involve their biocompatibility and their ability to efficiently target molecular recognition sites. Due to their intrinsic characteristics, self-assembled peptide micro/nanostructures are capable to load both hydrophobic and hydrophilic drugs, and they are suitable to achieve a triggered drug delivery at disease sites by inserting in their structure's stimuli-responsive moieties. The focus of this review was to summarize the most recent and significant studies on self-assembled peptides with an emphasis on their application in the biomedical field.

Indexed as

Drug Delivery SystemsHydrogelsHydrophobic and Hydrophilic InteractionsNanostructuresPeptidesHydrogelsPeptidesbiomaterialsdrug deliveryhydrogelSAPsself-assemblytissue regeneration

Identifiers

PMID34884467
PMCPMC8657556
OpenAlexW3216947954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.