Evidence map›Paper›PMID 34884460›Full record

ArticleInternational journal of molecular sciences2021

Paradigmatic De Novo

Ana Santos-Gómez, Federico Miguez-Cabello, Natalia Juliá-Palacios, Deyanira García-Navas, Víctor Soto-Insuga, Juan J García-Peñas, Patricia Fuentes, Salvador Ibáñez-Micó, Laura Cuesta, Ramón Cancho and 9 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. The curious absence of psychosis in GRIN1-related neurodevelopmental disorder.European archives of psychiatry and clinical neuroscience · 2025
    Article
  3. Article
  4. Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 1 country.

Ana Santos-GómezNeurophysiology Laboratory, Department of Biomedicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.
Federico Miguez-CabelloNeurophysiology Laboratory, Department of Biomedicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.
Natalia Juliá-PalaciosNeurometabolic Unit, Department of Neurology, Hospital Sant Joan de Déu-CIBERER, 08950 Barcelona, Spain.
Deyanira García-NavasDepartment of Pediatric Neurology, Hospital Universitario San Pedro de Alcántara, 10001 Cáceres, Spain.
Víctor Soto-InsugaNeurology Service, Hospital Niño Jesús, 28009 Madrid, Spain.
Juan J García-PeñasNeurology Service, Hospital Niño Jesús, 28009 Madrid, Spain.
Patricia FuentesNeuropediatrics Unit, Hospital Clínico Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0002-5486-6796
Salvador Ibáñez-MicóPediatric Neurology Unit, Arrixaca Universitary Hospital, 30120 Murcia, Spain.ORCID 0000-0003-4582-6511
Laura CuestaDepartment of Paediatrics Neurology, Hospital de Manises, 46940 Valencia, Spain.
Ramón CanchoPediatric Neurology, Department of Pediatrics, Hospital Universitario Río Hortega, 47012 Valladolid, Spain.
Patricia Andreo-LilloNeuropediatric Unit, Pediatric Department, University Hospital of Sant Joan d'Alacant, 03550 Sant Joan d'Alacant, Spain.
Gema Gutiérrez-AguilarPediatrics Unit, Hospital Universitario de Jerez de la Frontera, 11407 Jerez de la Frontera, Spain.
Olga Alonso-LuengoDepartment of Pediatrics, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
Ignacio MálagaChild Neurology Unit, Pediatrics Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.ORCID 0000-0003-4074-6870
Antonio Hedrera-FernándezChild Neurology Unit, Pediatrics Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Àngels García-CazorlaNeurometabolic Unit, Department of Neurology, Hospital Sant Joan de Déu-CIBERER, 08950 Barcelona, Spain.
David SotoNeurophysiology Laboratory, Department of Biomedicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.
Mireia OlivellaBioinfomatics and Medical Statistics Group, University of Vic-Central University of Catalonia, 08500 Vic, Spain.
Xavier AltafajNeurophysiology Laboratory, Department of Biomedicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Infantil Universitario Niño Jesús · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitario Central de Asturias · ESHospital de Manises · ESHospital Jerez Puerta del Sur · ESHospital San Pedro de Alcántara · ESHospital Universitario Río Hortega · ESHospital Universitario Virgen de la Arrixaca · ESHospital Universitario Virgen del Rocío · ESHospital Universitari Sant Joan D'Alacant · ESUniversitat de Vic - Universitat Central de Catalunya · ES

Funding

Instituto de Salud Carlos III PI19/00348
6 · The paper itself

Abstract

backgroundGRIN-related disorders (GRD), the so-called grinpathies, is a group of rare encephalopathies caused by mutations affecting

methodsIn this study, we aimed to delineate the structural and functional alterations of

resultsPatients harbouring

conclusionsOur findings show a strong correlation between

Indexed as

MutationAdolescentAnimalsBrain DiseasesChildChild, PreschoolChlorocebus aethiopsCohort StudiesCOS CellsFemaleHEK293 CellsHumansInfantMaleModels, MolecularNerve Tissue ProteinsGRIN1 protein, humanNerve Tissue ProteinsReceptors, N-Methyl-D-Aspartateglutamatergic neurotransmissionGRIN-related disordersneurodevelopmental disordersNMDA receptors

Identifiers

PMID34884460
PMCPMC8657601
OpenAlexW3216061459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.