Evidence map›Paper›PMID 34884447›Full record

ArticleInternational journal of molecular sciences2021

Intracellular Exposure Dose-Associated Susceptibility of Steatotic Hepatocytes to Metallic Nanoparticles.

Xiaoli Zhang, Yongyi Wei, Chengjun Li, Weiyu Wang, Rui Zhang, Jianbo Jia, Bing Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Hepatotoxicity of titanium dioxide nanoparticles.Journal of applied toxicology : JAT · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaoli ZhangKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Yongyi WeiSchool of Environmental Science and Engineering, Shandong University, Qingdao 266237, China.
Chengjun LiKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Weiyu WangKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Rui ZhangKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Jianbo JiaKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Bing YanKey Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay Area, Guangzhou University, Guangzhou 510006, China.
Guangzhou University · CNShandong University · CN

Funding

Basic and Applied Basic Research Foundation of Guangzhou, China 202102020399introduced innovative R&D team project under the "The Pearl River Talent Recruitment Pro-gram" of Guangdong Province 2019ZT08L387National Natural Science Foundation of China 21906035National Natural Science Foundation of China 22036002
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD), mainly characterized by the accumulation of excess fat in hepatocytes, is the most prevalent liver disorder afflicting ~25% of adults worldwide. In vivo studies have shown that adult rodents with NAFLD were more sensitive to metallic nanoparticles (MNPs) than healthy MNPs. However, due to the complex interactions between various cell types in a fatty liver, it has become a major challenge to reveal the toxic effects of MNPs to specific types of liver cells such as steatotic hepatocytes. In this study, we reported the susceptibility of steatotic hepatocytes in cytotoxicity and the induction of oxidative stress to direct exposures to MNPs with different components (silver, ZrO

Indexed as

Cell ProliferationCell SurvivalDose-Response Relationship, DrugHep G2 CellsHumansLipid MetabolismMetal NanoparticlesModels, BiologicalNon-alcoholic Fatty Liver DiseaseOleic AcidOxidative StressParticle SizeReactive Oxygen SpeciesSilverTitaniumZirconiumOleic AcidReactive Oxygen SpeciesSilverTitaniumtitanium dioxideZirconiumzirconium oxideintracellular exposure doselipid metabolismnanotoxicitysteatotic hepatocytessusceptible population

Identifiers

PMID34884447
PMCPMC8657991
OpenAlexW3215393326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.