Evidence map›Paper›PMID 34884399›Full record

ArticleJournal of clinical medicine2021

Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease and Healthy Controls: A Cohort Study.

Barbara Zapała, Tomasz Stefura, Magdalena Wójcik-Pędziwiatr, Radosław Kabut, Marta Bałajewicz-Nowak, Tomasz Milewicz, Alicja Dudek, Anastazja Stój, Monika Rudzińska-Bar

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 43 citations in OpenAlex.

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  8. International journal of molecular sciences · 2025
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  17. Frontiers in neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Barbara ZapałaDepartment of Clinical Biochemistry, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Tomasz Stefura2(nd) Department of General Surgery, Jagiellonian University Medical College, 31-008 Krakow, Poland.ORCID 0000-0003-4208-7872
Magdalena Wójcik-PędziwiatrDepartment of Neurology, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland.
Radosław KabutInstitute of Psychology, Jagiellonian University, 30-060 Krakow, Poland.
Marta Bałajewicz-NowakDepartment of Gynecology and Obstetrics, Jagiellonian University Medical College, 31-501 Krakow, Poland.
Tomasz MilewiczDepartment of Gynaecological Endocrinology and Gynaecology, Jagiellonian University Medical College, 31-501 Krakow, Poland.
Alicja Dudek2(nd) Department of General Surgery, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Anastazja StójDepartment of Hematology Diagnostics and Genetics, The University Hospital, 30-688 Krakow, Poland.
Monika Rudzińska-BarDepartment of Neurology, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland.ORCID 0000-0002-1453-6856
Jagiellonian University · PLAndrzej Frycz Modrzewski Krakow University · PLUniversity School of Physical Education in Kraków · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiome and colonic inflammation can be associated with the predisposition and progression of Parkinson's disease (PD). The presented study aimed to compare gastrointestinal microbiota composition between patients diagnosed with PD and treated only with Levodopa to healthy controls. In this prospective study, patients were recruited in 1 academic hospital from July 2019 to July 2020. The detailed demographic data and medical history were collected using a set of questionnaires. Fecal samples were obtained from all participants. Next-Generation Sequencing was used to assess the microbiota composition. The endpoint was the difference in composition of the gut microbiota. In this study, we enrolled 27 hospitalized PD patients with well-controlled symptoms. The control group included 44 healthy subjects matched for age. Among PD patients, our results presented a higher abundance of

Indexed as

gut microbiomemicrobiotaParkinson’s disease

Identifiers

PMID34884399
PMCPMC8658639
OpenAlexW4200023074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.