Evidence map›Paper›PMID 34884353›Full record

ArticleJournal of clinical medicine2021

Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France.

Maxime Volff, David Tonon, Youri Bommel, Noémie Peres, David Lagier, Geoffray Agard, Alexis Jacquier, Axel Bartoli, Julien Carvelli, Howard Max and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Maxime VolffDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
David TononDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Youri BommelDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Noémie PeresDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
David LagierDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Geoffray AgardDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Alexis JacquierDepartment of Radiology and Cardiovascular Imaging, UMR 7339, CNRS, CRMBM CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique), Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Axel BartoliDepartment of Radiology and Cardiovascular Imaging, UMR 7339, CNRS, CRMBM CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d'Exploration Métaboliques par Résonance Magnétique), Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Julien CarvelliEmergency and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Howard MaxDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Pierre SimeoneDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Valery BlascoRéanimation Polyvalente des Pathologies du Foie, AP-HM, CEDEX 05, 13385 Marseille, France.
Bruno PasteneService Anesthésie et Réanimation, Hôpital Nord, AP-HM, Aix-Marseille University, CEDEX 20, 13915 Marseille, France.
Anderson LoundouLaboratoire de Santé Publique, Unité de Recherche EA 3279, Faculté de Médecine de Marseille, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Laurent BoyerCEReSS-Health Service Research and Quality of Life Center, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Marc LeoneService Anesthésie et Réanimation, Hôpital Nord, AP-HM, Aix-Marseille University, CEDEX 20, 13915 Marseille, France.
Lionel VellyDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Jeremy BourenneEmergency and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Salah BoussenDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.
Mickaël BobotService de Médecine Intensive Réanimation, AP-HM, Hôpital Nord, CEDEX 20, 13915 Marseille, France.
Nicolas BruderDepartment of Anaesthesiology and Critical Care Medicine, University Hospital Timone, AP-HM, Aix-Marseille University, CEDEX 05, 13385 Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors.

methodsThis observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission.

resultsIncluded in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9-33) days and 29 (17-46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis.

conclusionIn this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.

Indexed as

acute respiratory distress syndromeCovid-19intensive care unitmechanical ventilationprognostic factorsSARS-CoV-2

Identifiers

PMID34884353
PMCPMC8658321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.