ArticleJournal of clinical medicine2021
Pulmonary Edema in COVID-19 Treated with Furosemide and Negative Fluid Balance (NEGBAL): A Different and Promising Approach.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05304702 (Lung Injury), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL): a Case-Control Study
Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Epidemiology and Current Challenges of Human Schistosomiasis Along the Shabelle River, Somali Regional State, Eastern Ethiopia.Acta parasitologica · 2025Article
- Nationwide Assessment of Pulmonary Function Testing Practices and Safety Compliance During the COVID-19 PandemicThoracic research and practice · 2025Article
- Article
- Frequency of dysnatremia in patients admitted with COVID-19 infection and its prognostic implication.The Journal of international medical research · 2023Article
- A Focused Review of the Initial Management of Patients with Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2023Article
- Outcomes of viral myocarditis in patients with and without COVID-19: a nationwide analysis from the United States.Annals of medicine and surgery (2012) · 2023Article
- Lung Injury in COVID-19 Has Pulmonary Edema as an Important Component and Treatment with Furosemide and Negative Fluid Balance (NEGBAL) Decreases Mortality.Journal of clinical medicine · 2023Article
- Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Two in one: Overlapping CT findings of COVID-19 and underlying lung diseases.Clinical imaging · 2023Review
- Special Issue "Pulmonary and Critical Care Practice in the Pandemic of COVID-19".Journal of clinical medicine · 2022Article
- Real-World Evidence for COVID-19 Delta Variant's Effects on the Digestive System and Protection of Inactivated Vaccines from a Medical Center in Yangzhou, China: A Retrospective Observational Study.International journal of clinical practice · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In COVID-19, pulmonary edema has been attributed to "cytokine storm". However, it is known that SARS-CoV2 promotes angiotensin-converting enzyme 2 deficit, increases angiotensin II, and this triggers volume overload. Our report is based on COVID-19 patients with tomographic evidence of pulmonary edema and volume overload to whom established a standard treatment with diuretic (furosemide) guided by objectives: Negative Fluid Balance (NEGBAL approach). Retrospective observational study. We reviewed data from medical records: demographic, clinical, laboratory, blood gas, and chest tomography (CT) before and while undergoing NEGBAL, from 20 critically ill patients. Once the NEGBAL strategy was started, no patient required mechanical ventilation. All cases reverted to respiratory failure with NEGBAL, but subsequently two patients died from sepsis and acute myocardial infarction (AMI). The regressive analysis between PaO2/FiO2BAL and NEGBAL demonstrated correlation (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.