Evidence map›Paper›PMID 34884173›Full record

ArticleJournal of clinical medicine2021

Serum from Patients with Severe Alcoholic Liver Cirrhosis Inhibits Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells.

Mare Mechelinck, Miriam Peschel, Moriz A Habigt, Daniela Kroy, Michael Lehrke, Marius J Helmedag, Rolf Rossaint, Matthias Barton, Marc Hein

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty.International journal of molecular sciences · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mare MechelinckDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-8928-338X
Miriam PeschelDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Moriz A HabigtDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1445-608X
Daniela KroyDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Michael LehrkeDepartment of Internal Medicine I, Cardiology, Angiology and Internal Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Marius J HelmedagDepartment of General, Visceral and Transplantation Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Rolf RossaintDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Matthias BartonMolecular Internal Medicine, University of Zürich, 8057 Zürich, Switzerland.
Marc HeinDepartment of Anesthesiology, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-9436-7353
RWTH Aachen University · DEUniversity of Zurich · CH

Funding

Ministry of Science and Research of the State of North Rhine-Westphalia START-13/17Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 108 258Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 122 504
6 · The paper itself

Abstract

Liver cirrhosis has been associated with an increased risk of coronary artery disease and clinical complications following percutaneous coronary revascularization. The present study is based on the hypothesis that cirrhosis may influence intimal hyperplasia following PCI. Sera from 10 patients with alcoholic liver cirrhosis and 10 age-matched healthy controls were used to stimulate cultured human coronary artery smooth muscle cells (HCASMC) for 48 h. HCASMC proliferation, migration, gene expression and apoptosis were investigated. Serum concentrations of growth factors and markers of liver function were also determined in patients and healthy controls. Treatment of HCASMC with patient sera reduced cell proliferation and migration (

Indexed as

cell proliferationcoronary artery diseaseliver cirrhosispercutaneous coronary interventionsmooth muscle cells

Identifiers

PMID34884173
PMCPMC8658341
OpenAlexW3215249620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.