Evidence map›Paper›PMID 34884060›Full record

ArticleSensors (Basel, Switzerland)2021

Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme.

Muhammad Musaddiq Shah, Wen Ren, Joseph Irudayaraj, Abdulrahim A Sajini, Muhammad Ishtiaq Ali, Bashir Ahmad

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Streptavidin-DisplayingSensors (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Current Advances in Aptasensors for Pesticide Detection.Topics in current chemistry (Cham) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Musaddiq ShahDepartment of Biological Sciences, International Islamic University, Islamabad 44000, Pakistan.
Wen RenDepartment of Bioengineering, The University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Joseph IrudayarajDepartment of Bioengineering, The University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-0630-1520
Abdulrahim A SajiniDepartment of Biomedical Engineering, The Khalifa University, Abu Dhabi 127788, United Arab Emirates.ORCID 0000-0002-8600-3899
Muhammad Ishtiaq AliDepartment of Microbiology, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Bashir AhmadDepartment of Biological Sciences, International Islamic University, Islamabad 44000, Pakistan.ORCID 0000-0001-6047-3334

Funding

Khalifa University of Science and Technology Competitive Internal Research Award CIRA-ADEK and by Abu Dhabi Award for Re-search Excellence (AARE) 2019
6 · The paper itself

Abstract

Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). A robust and sensitive detection system of OPs utilising the enzyme mimic potential of the cysteamine capped gold nanoparticles (C-AuNPs) was developed. The detection assay was performed by stepwise addition of AChE, parathion ethyl (PE)-a candidate OP, acetylcholine chloride (ACh), C-AuNPs, and 3, 3', 5, 5'-tetramethylbenzidine (TMB) in the buffer solution. The whole sensing protocol completes in 30-40 min, including both incubations. The Transmission Electron Microscopy (TEM) results indicated that the NPs are spherical and have an average size of 13.24 nm. The monomers of C-AuNPs exhibited intense catalytic activity (nanozyme) for the oxidization of TMB, revealed by the production of instant blue colour and confirmed by a sharp peak at 652 nm. The proposed biosensor's detection limit and linear ranges were 5.8 ng·mL

Indexed as

Biosensing TechniquesMetal NanoparticlesPesticidesAcetylcholinesteraseColorimetryCysteamineGoldOrganophosphatesAcetylcholinesteraseCysteamineGoldOrganophosphatesPesticidesacetylcholinesterase inhibitorscolorimetric biosensornanozymeneurotoxinparathion ethylpesticide intoxication

Identifiers

PMID34884060
PMCPMC8659924

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.