Evidence map›Paper›PMID 34884031›Full record

ArticleSensors (Basel, Switzerland)2021

Automatic Segmentation of the Retinal Nerve Fiber Layer by Means of Mathematical Morphology and Deformable Models in 2D Optical Coherence Tomography Imaging.

Rafael Berenguer-Vidal, Rafael Verdú-Monedero, Juan Morales-Sánchez, Inmaculada Sellés-Navarro, Rocío Del Amor, Gabriel García, Valery Naranjo

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rafael Berenguer-VidalDepartamento de Ciencias Politécnicas, Campus de los Jerónimos, Universidad Católica de Murcia UCAM, 30107 Murcia, Spain.ORCID 0000-0001-9345-2804
Rafael Verdú-MonederoDepartamento de Tecnologías de la Información y Comunicaciones, Campus Muralla del Mar, Universidad Politécnica de Cartagena, 30202 Cartagena, Spain.ORCID 0000-0001-9227-7397
Juan Morales-SánchezDepartamento de Tecnologías de la Información y Comunicaciones, Campus Muralla del Mar, Universidad Politécnica de Cartagena, 30202 Cartagena, Spain.
Inmaculada Sellés-NavarroServicio de Oftalmología, Hospital General Universitario Reina Sofía, 30003 Murcia, Spain.ORCID 0000-0002-8757-2559
Rocío Del AmorInstituto de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-5342-2093
Gabriel GarcíaInstituto de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-9900-886X
Valery NaranjoInstituto de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-0181-3412
Universitat Politècnica de València · ESUniversidad Politécnica de Cartagena · ESHospital Reina Sofía de Murcia · ESUniversidad Católica de Murcia · ES

Funding

Fundación Seneca 20901/PI/18Instituto de Salud Carlos III AES2017-PI17/00771, AES2017-PI17/00821Spanish Ministry of Economy and Competitiveness PID2019-105142RB-C21 (AI4SKIN)State Research Spanish Agency PTA2017-14610-IUniversitat Politècnica de València PAID-01-20
6 · The paper itself

Abstract

Glaucoma is a neurodegenerative disease process that leads to progressive damage of the optic nerve to produce visual impairment and blindness. Spectral-domain OCT technology enables peripapillary circular scans of the retina and the measurement of the thickness of the retinal nerve fiber layer (RNFL) for the assessment of the disease status or progression in glaucoma patients. This paper describes a new approach to segment and measure the retinal nerve fiber layer in peripapillary OCT images. The proposed method consists of two stages. In the first one, morphological operators robustly detect the coarse location of the layer boundaries, despite the speckle noise and diverse artifacts in the OCT image. In the second stage, deformable models are initialized with the results of the previous stage to perform a fine segmentation of the boundaries, providing an accurate measurement of the entire RNFL. The results of the RNFL segmentation were qualitatively assessed by ophthalmologists, and the measurements of the thickness of the RNFL were quantitatively compared with those provided by the OCT inbuilt software as well as the state-of-the-art methods.

Indexed as

Neurodegenerative DiseasesTomography, Optical CoherenceHumansNerve FibersRetinaRetinal Ganglion Cellsactive contoursautomatic layer segmentationglaucomamathematical morphologyoptical coherence tomography (OCT)peripapillary OCTretinal imaging analysis

Identifiers

PMID34884031
PMCPMC8659929
OpenAlexW3217110927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.