ArticleSensors (Basel, Switzerland)2021
Muscle Synergies and Clinical Outcome Measures Describe Different Factors of Upper Limb Motor Function in Stroke Survivors Undergoing Rehabilitation in a Virtual Reality Environment.
Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness.eLife · 2026Article
- sEMG-Based Muscle Synergy Analysis and Functional Driving Ratio for Quantitative Assessment During Robot-Assisted Upper-Limb Rehabilitation.Sensors (Basel, Switzerland) · 2026Article
- Biomechanical Modeling, Muscle Synergy-Based Rehabilitation Assessment, and Real-Time Fatigue Monitoring for Piano-Integrated Upper Limb Therapy.Biomimetics (Basel, Switzerland) · 2025Article
- Can EMG-Derived Upper Limb Muscle Synergies Serve as Markers for Post-Stroke Motor Assessment and Prediction of Rehabilitation Outcome?Sensors (Basel, Switzerland) · 2025Article
- The role of muscle synergies and task constraints on upper limb motor impairment after stroke.Experimental brain research · 2025Article
- Muscle synergies in upper limb stroke rehabilitation: a scoping review.European journal of physical and rehabilitation medicine · 2024Article
- A Novel TCN-LSTM Hybrid Model for sEMG-Based Continuous Estimation of Wrist Joint Angles.Sensors (Basel, Switzerland) · 2024Article
- Transferring Sensor-Based Assessments to Clinical Practice: The Case of Muscle Synergies.Sensors (Basel, Switzerland) · 2024Article
- Muscle synergies for evaluating upper limb in clinical applications: A systematic review.Heliyon · 2023Review
- A narrative review of the use of a cutting-edge virtual reality rehabilitation technology in neurological and neuropsychological rehabilitation.NeuroRehabilitation · 2023Review
- Recent developments in muscle synergy analysis in young people with neurodevelopmental diseases: A Systematic Review.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have investigated muscle synergies as biomarkers for stroke, but it remains controversial if muscle synergies and clinical observation convey the same information on motor impairment. We aim to identify whether muscle synergies and clinical scales convey the same information or not. Post-stroke patients were administered an upper limb treatment. Before (T0) and after (T1) treatment, we assessed motor performance with clinical scales and motor output with EMG-derived muscle synergies. We implemented an exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA) to identify the underlying relationships among all variables, at T0 and T1, and a general linear regression model to infer any relationships between the similarity between the affected and unaffected synergies (Median-sp) and clinical outcomes at T0. Clinical variables improved with rehabilitation whereas muscle-synergy parameters did not show any significant change. EFA and CFA showed that clinical variables and muscle-synergy parameters (except Median-sp) were grouped into different factors. Regression model showed that Median-sp could be well predicted by clinical scales. The information underlying clinical scales and muscle synergies are therefore different. However, clinical scales well predicted the similarity between the affected and unaffected synergies. Our results may have implications on personalizing rehabilitation protocols.
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