Evidence map›Paper›PMID 34883702›Full record

ReviewPolymers2021

Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions.

Mahshid Hafezi, Saied Nouri Khorasani, Mohadeseh Zare, Rasoul Esmaeely Neisiany, Pooya Davoodi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
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  4. Assessment of Bovine Collagen Manufactured via Cellular Agriculture.ACS biomaterials science & engineering · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mahshid HafeziDepartment of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.ORCID 0000-0003-4545-4041
Saied Nouri KhorasaniDepartment of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Mohadeseh ZareSchool of Metallurgy and Materials, University of Birmingham, Birmingham B15 2TT, UK.
Rasoul Esmaeely NeisianyDepartment of Materials and Polymer Engineering, Faculty of Engineering, Hakim Sabzevari University, Sabzevar 96179-76487, Iran.ORCID 0000-0002-6988-3898
Pooya DavoodiSchool of Pharmacy and Bioengineering, Hornbeam Building, Keele University, Staffordshire ST5 5BG, UK.ORCID 0000-0002-9847-8066
Isfahan University of Technology · IRHakim Sabzevari University · IRKeele University · GBUniversity of Birmingham · GB

Funding

Keele University School of Pharmacy and Bioengineering starting grant and Faculty Research Award 2021
6 · The paper itself

Abstract

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tissue. The need to overcome the restrictions of these therapies for cartilage regeneration has expanded the field of cartilage tissue engineering (CTE), in which novel engineering and biological approaches are introduced to accelerate the development of new biomimetic cartilage to replace the injured tissue. Until now, a wide range of hydrogels and cell sources have been employed for CTE to either recapitulate microenvironmental cues during a new tissue growth or to compel the recovery of cartilaginous structures via manipulating biochemical and biomechanical properties of the original tissue. Towards modifying current cartilage treatments, advanced hydrogels have been designed and synthesized in recent years to improve network crosslinking and self-recovery of implanted scaffolds after damage in vivo. This review focused on the recent advances in CTE, especially self-healing hydrogels. The article firstly presents the cartilage tissue, its defects, and treatments. Subsequently, introduces CTE and summarizes the polymeric hydrogels and their advances. Furthermore, characterizations, the advantages, and disadvantages of advanced hydrogels such as multi-materials, IPNs, nanomaterials, and supramolecular are discussed. Afterward, the self-healing hydrogels in CTE, mechanisms, and the physical and chemical methods for the synthesis of such hydrogels for improving the reformation of CTE are introduced. The article then briefly describes the fabrication methods in CTE. Finally, this review presents a conclusion of prevalent challenges and future outlooks for self-healing hydrogels in CTE applications.

Indexed as

articular cartilagepolymeric hydrogelsself-healingtissue engineering

Identifiers

PMID34883702
PMCPMC8659862
OpenAlexW3214737862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.