Synthesis and Coordination Properties of a Water-Soluble Material by Cross-Linking Low Molecular Weight Polyethyleneimine with Armed Cyclotriveratrilene.

Yoke Mooi Ng, Paolo Coghi, Jerome P L Ng, Fayaz Ali, Vincent Kam Wai Wong, Carmine Coluccini

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Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yoke Mooi NgInstitute of New Drug Development, College of Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.

Paolo CoghiSchool of Pharmacy, Macau University of Science and Technology, Macau 999078, China.ORCID 0000-0002-0015-1453

Jerome P L NgNeher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.

Fayaz AliDepartment Chemistry, Abbottabad University of Science and Technology, Abbottabad 22010, Pakistan.

Vincent Kam Wai WongNeher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.

Carmine ColucciniInstitute of New Drug Development, College of Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.

Funding

China Medical University In- 461 ternal grant CMU109-N-25FDCT grant from the Macao Science 462 and Technology Development Fund Project code 0087/2020/AMOST, Ministry of Science and Technology, Taiwan MOST 107-2113-M-039-008-MY3, MOST 110-2113-M-039-001

6 · The paper itself

Abstract

In this study, a full organic and water-soluble material was synthesized by coupling low molecular weight polyethylenimine (PEI-800) with cyclotriveratrilene (CTV). The water-soluble cross-linked polymer contains hydrophobic holes with a high coordination capability towards different organic drug molecules. The coordinating capability towards hydrophilic drugs (doxorubicin, gatifloxacin and sinomenine) and hydrophobic drugs (camptothecin and celastrol) was analyzed in an aqueous medium by using NMR, UV-Vis and emission spectroscopies. The coordination of drug molecules with the armed CTV unit through hydrophobic interactions was observed. In particular, celastrol exhibited more ionic interactions with the PEI moiety of the hosting system. In the case of doxorubicin, the host-guest detachment was induced by the addition of ammonium chloride, suggesting that the intracellular environment can facilitate the release of the drug molecules.

Indexed as

cyclotriveratrilenehydrophilic materialhydrophobic interactionpolyethyleneiminepolymer cross-linking

Identifiers

PMID34883636

DOI10.3390/polym13234133

PMCPMC8659696

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