Evidence map›Paper›PMID 34883582›Full record

ArticlePolymers2021

Highly Efficient Synthesis of Type B Gelatin and Low Molecular Weight Chitosan Nanoparticles: Potential Applications as Bioactive Molecule Carriers and Cell-Penetrating Agents.

Cristina Gonzalez-Melo, Andres J Garcia-Brand, Valentina Quezada, Luis H Reyes, Carolina Muñoz-Camargo, Juan C Cruz

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Gelatin and lipidoid integrate to createBioactive materials · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina Gonzalez-MeloDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá 111711, Colombia.ORCID 0000-0003-3989-0840
Andres J Garcia-BrandDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá 111711, Colombia.ORCID 0000-0002-1716-1893
Valentina QuezadaDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá 111711, Colombia.ORCID 0000-0003-2053-1303
Luis H ReyesProduct and Process Design Group (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0001-7251-5298
Carolina Muñoz-CamargoDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá 111711, Colombia.ORCID 0000-0001-6238-9021
Juan C CruzDepartment of Biomedical Engineering, Universidad de Los Andes, Bogotá 111711, Colombia.ORCID 0000-0002-7790-7546

Funding

Fundación Santafé-Uniandes production of recombinant antimicrobial peptides to modify materials of biomedical interestMinciencias 120484467244
6 · The paper itself

Abstract

Gelatin and chitosan nanoparticles have been widely used in pharmaceutical, biomedical, and nanofood applications due to their high biocompatibility and biodegradability. This study proposed a highly efficient synthesis method for type B gelatin and low-molecular-weight (LMW) chitosan nanoparticles. Gelatin nanoparticles (GNPs) were synthesized by the double desolvation method and the chitosan nanoparticles (CNPs) by the ionic gelation method. The sizes of the obtained CNPs and GNPs (373 ± 71 nm and 244 ± 67 nm, respectively) and zeta potential (+36.60 ± 3.25 mV and -13.42 ± 1.16 mV, respectively) were determined via dynamic light scattering. Morphology and size were verified utilizing SEM and TEM images. Finally, their biocompatibility was tested to assure their potential applicability as bioactive molecule carriers and cell-penetrating agents.

Indexed as

LMW chitosannanoparticlessynthesistype B gelatin

Identifiers

PMID34883582
PMCPMC8659274

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.