ArticleNature2022
Malaria protection due to sickle haemoglobin depends on parasite genotype.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.BMC medicine · 2023Trial
- Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT).The Lancet. Child & adolescent health · 2022Trial
- Sickle cell haemoglobin status shapes malaria parasite genotype in asymptomatic infections.Nature microbiology · 2026Article
- Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients.PLoS pathogens · 2026Article
- Integrated lipidomic and transcriptomic profiling of the host response in human malaria.Genome biology · 2026Article
- Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana.Malaria journal · 2026Article
- Genetic variants in red blood cell adhesion-related genes influence the severity of sickle cell anemia in a malaria-endemic region : Short title: Genetic variants in red blood cell adhesion-related genes in sickle cell anemia.Molecular biology reports · 2026Article
- Article
- Dissecting pleiotropy to gain mechanistic insights into human disease.Nature reviews. Genetics · 2026Review
- Major features of parasite adaptation revealed by genomes of Plasmodium falciparum population samples archived for over 50 years.Communications biology · 2026Article
- Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia.Nature communications · 2025Article
- Phenotypic screens reveal Plasmodium falciparum genetic factors associated with infection of sickle-trait cells.Blood cells, molecules & diseases · 2025Article
- Mendelian Randomization and Infection: Pitfalls and Promises.The Journal of infectious diseases · 2025Review
- Article
- Marked heterogeneity in malaria infection rate in a Malian longitudinal cohort.Nature communications · 2025Article
- Phylogenetics and genomic variation of Hepatocystis isolated from shotgun sequencing of wild primate hosts.PLoS pathogens · 2025Article
- A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum.Molecular microbiology · 2025Article
- No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank.Behavior genetics · 2025Article
- Infections in sickle cell disease.Haematologica · 2025Review
- Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Molecular biology and evolution · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 8 institutions in 4 countries.
Gavin BandWellcome Centre for Human Genetics, University of Oxford, Oxford, UK. gavin.band@well.ox.ac.uk.ORCID http://orcid.org/0000-0002-1710-9024
Ellen M LefflerWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0002-1614-9366
Muminatou JallowMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Fatoumatta Sisay-JoofMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Carolyne M NdilaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Alexander W MachariaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0001-5364-9610
Christina HubbartWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9576-9581
Anna E JeffreysWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Kate RowlandsWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Thuy NguyenWellcome Sanger Institute, Hinxton, Cambridge, UK.
Sónia GonçalvesWellcome Sanger Institute, Hinxton, Cambridge, UK.
Cristina V ArianiWellcome Sanger Institute, Hinxton, Cambridge, UK.
Jim StalkerWellcome Sanger Institute, Hinxton, Cambridge, UK.
Richard D PearsonWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0002-7386-3566
Roberto AmatoWellcome Sanger Institute, Hinxton, Cambridge, UK.
Eleanor DruryWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0002-9887-6961
Giorgio SirugoMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Umberto d'AlessandroMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Kalifa A BojangMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Kevin MarshKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0001-8377-5466
Norbert PeshuKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Joseph W SaelensDivision of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.
Mahamadou DiakitéMalaria Research and Training Center, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.
Steve M TaylorDivision of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.
David J ConwayMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.ORCID http://orcid.org/0000-0002-8711-3037
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0003-4456-2382
Kirk A RockettWellcome Centre for Human Genetics, University of Oxford, Oxford, UK. kirk.rockett@well.ox.ac.uk.
Dominic P KwiatkowskiWellcome Centre for Human Genetics, University of Oxford, Oxford, UK. dominic@sanger.ac.uk.ORCID http://orcid.org/0000-0002-5023-0176
Wellcome Sanger Institute · GBCentre for Human Genetics · GBKenya Medical Research Institute · KEMRC Unit the Gambia · GMDuke University · USEdward Francis Small Teaching Hospital · GMLondon School of Hygiene & Tropical Medicine · GBUniversity of Utah · US
Funding
Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5MImpact of Sickle-Trait on Transcriptional Regulation in P. Falciparum ParasitesR21AI125988 · NIAID · DUKE UNIVERSITY · PI TAYLOR, STEVE MYER · 2017 to 2018
$431kMedical Research Council G0600230Medical Research Council G0600718Medical Research Council MC_UP_A900_1118Medical Research Council MC_UP_A900_1119Medical Research Council MR/M006212/1NCATS NIH HHS UL1 TR002553NIAID NIH HHS R21 AI125988Wellcome TrustWellcome Trust 090770/Z/09/ZWellcome Trust 202800/Z/16/ZWellcome Trust 203141/Z/16/ZWellcome Trust 204911/Z/16/ZWellcome Trust 206194Wellcome Trust WT077383/Z/05/Z
Abstract
Host genetic factors can confer resistance against malaria
Indexed as
GenotypeAllelesAnimalsChildFemaleGambiaGenes, ProtozoanHemoglobin, SickleHost AdaptationHumansKenyaLinkage DisequilibriumMalaria, FalciparumMaleParasitesPlasmodium falciparumHemoglobin, Sickle
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.