Evidence map›Paper›PMID 34883422›Full record

ArticleChild abuse & neglect2022

Executive functions as a mediator of childhood maltreatment on adult psychopathology: A longitudinal mediation analysis comparing maltreatment factor models.

Kyle R Kent, Christian J Hopfer, Robin P Corley, Michael C Stallings

Abstract read
In one paragraph

Article in Child abuse & neglect, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyle R KentDepartment of Psychology and Neuroscience, University of Colorado, Boulder, United States of America. Electronic address: kyle.kent@colorado.edu.
Christian J HopferDepartment of Psychiatry, University of Colorado, Denver, United States of America.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, United States of America.
Michael C StallingsDepartment of Psychology and Neuroscience, University of Colorado, Boulder, United States of America; Institute for Behavioral Genetics, University of Colorado, Boulder, United States of America.

Funding

The Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin CohortsR01DA042755 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarrod Martin Ellingson, SOO H RHEE · 2017 to 2026
$9.9M
Genetics and Progression of Early-onset Substance Dependence and HIV RiskR01DA035804 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J, STALLINGS, MICHAEL CRAIG · 2014 to 2018
$4.9M
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders ResearchK24DA032555 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J · 2013 to 2022
$1.9M
NIDA NIH HHS K24 DA032555NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA042755
6 · The paper itself

Abstract

backgroundChildhood maltreatment (CM), executive functions (EFs), and psychiatric disorders all correlate highly. Changes in EFs during adolescence related to CM present a possible mediating mechanism for the development of psychiatric disorders, yet no study has analyzed this longitudinally while comparing predictive capacity of different CM factor structures. We hypothesized that changes in EFs from adolescence to adulthood would mediate, in part, associations between CM, internalizing disorders (INT), and anti-social personality disorder (ASPD) while different subtypes of CM would differentially predict INT and ASPD.

objectiveThis study longitudinally examined the mediating effects of EFs on associations between CM, INT, and ASPD while comparing prediction of two CM factor structures.

participantsHigh-risk subjects selected for drug use in adolescence (N = 658) from mean ages 16 to 23.

methodsA Bayesian structural equation model was deployed to analyze change in EFs as a mediator of the relationship between CM and adult INT and ASPD. CM was measured using two factor structures: a single overall factor and four correlated factors representing CM subtypes.

resultsCM significantly predicted INT and ASPD but there was no evidence that the relationship was substantially mediated through EFs. High correlations among subtypes of CM limited the unique predictions of each subtype on INT and ASPD.

conclusionIn this high-risk sample, the collinearity of CM subtypes obscured their predictions of outcome measures supporting the use of one CM factor. EFs did not significantly mediate associations between CM and psychiatric disorders, but further research on these relationships is warranted.

Indexed as

Child AbuseMental DisordersAdolescentAdultBayes TheoremChildExecutive FunctionHumansMediation AnalysisYoung AdultBayesian structural equation modelChildhood maltreatmentExecutive functionsInternalizing disordersMediation

Identifiers

PMID34883422
PMCPMC8859768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.