Evidence map›Paper›PMID 34883243›Full record

ArticleJoint bone spine2022

Systematic assessment of the humoral response against SARS-CoV-2 in a French cohort of 283 patients with rheumatic diseases.

Clothilde Gros, Alice-Andrée Mariaggi, Jean-François Meritet, Emma André, Margaux Boisson, Alice Combier, Elise Descamps, Camelia Frantz, Sarah Wanono, Jacques Morel and 4 more

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Article in Joint bone spine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Clothilde GrosService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Alice-Andrée MariaggiService de Virologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Jean-François MeritetService de Virologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Emma AndréService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Margaux BoissonService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Alice CombierService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Elise DescampsService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Camelia FrantzService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Sarah WanonoService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Jacques MorelRheumatology department, CHU, University of Montpellier, Montpellier, France.
Jérôme AvouacService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Flore RozenbergService de Virologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Corinne Miceli-RichardService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France; Unité Mixte, Immunoregulation Unit, Institut Pasteur, AP-HP, Paris, France. Electronic address: corinne.miceli@aphp.fr.
Olivier FogelService de Rhumatologie, Paris Descartes Université, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the seroprevalence of SARS-CoV-2 infection in patients with rheumatic diseases and to specify the proportion of asymptomatic and symptomatic forms of COVID-19.

methodsWe screened for SARS-CoV-2 infection among spondyloarthritis (SpA, n=143) or rheumatoid arthritis (RA, n=140) patients in our outpatient clinic at Cochin Hospital in Paris between June and August 2020. We performed a qualitative SARS-CoV-2 serological test which detects IgG directed against the N nucleocapsid protein (anti-N) and, for some patients, against the Spike protein (anti-S). Descriptive analyses were managed.

resultsDuring June-August 2020, the SARS-CoV-2 seroprevalence rate in our population was 2.83% (8/283 patients) without significant difference between RA and SpA patients (2.14% and 3.5%, respectively). We report 11 out of 283 patients (3.8%) with a diagnosis of SARS-CoV-2 infection. Among these 11 patients, 1 patient was asymptomatic (9%) with a confirmed diagnosis of COVID-19 by anti-S serology. Of the 283 patients, 85% were under bDMARDs, mainly on rituximab (RTX) (n=44) and infliximab (IFX) (n=136).

conclusionsThe seroprevalence of SARS-CoV-2 in patients with rheumatic diseases, mainly under bDMARDs treatments, was 2.83%. Among infected patients, 9% were asymptomatic. Detecting SARS-CoV-2 infections could be based on the strategy using patients' interview and anti-N serology.

Indexed as

COVID-19Rheumatic DiseasesHumansSARS-CoV-2Seroepidemiologic StudiesSerologic TestsCOVID-19DMARDsRheumatoid arthritisSerologySpondyloarthritis

Identifiers

PMID34883243
PMCPMC8647388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.