SynthesisAgeing research reviews2022
Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis.
Synthesis in Ageing research reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 77 citations in OpenAlex.
- Influence of a 2-week transcutaneous auricular vagus nerve stimulation on memory: findings from a randomized placebo controlled trial in non-clinical adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Trial
- Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Relationship between cerebral white matter hyperintensities and autonomic function in older individuals with cerebral small vessel disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers.Journal of Alzheimer's disease : JAD · 2026Article
- Personalized cognitive enhancement for older adults: An aging-friendly closed-loop human-machine interface framework.Ageing research reviews · 2025Review
- Short-Term Effects of Visceral Manual Therapy on Autonomic Nervous System Modulation in Individuals with Clinically Based Bruxism: A Randomized Controlled Trial.Dentistry journal · 2025Article
- Correlative relationship between body mass index and heart rate variability in psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2025Article
- Age-related variations in heart rate variability profiles among patients with schizophrenia and major depressive disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- Heart rate variability and cognitive functions in adolescents with complex congenital heart disease.Pediatric research · 2025Article
- One-week test-retest recordings of resting cardiorespiratory data for reliability analysis.Scientific data · 2025Article
- Different association patterns of emotion regulation and heart rate variability in older and younger adults.Brain communications · 2025Article
- Hippocampal vascular supply and its mediating role in systemic physiological influences on hippocampal volume.Frontiers in aging neuroscience · 2025Article
- Implications of heart rate variability measured using wearable electrocardiogram devices in diagnosing Parkinson's disease and its association with neuroimaging biomarkers: a case-control study.Frontiers in aging neuroscience · 2025Article
- Brain mechanisms underlying the modulation of heart rate variability when accepting and reappraising emotions.Scientific reports · 2024Article
- Prediction of Mild Cognitive Impairment Status: Pilot Study of Machine Learning Models Based on Longitudinal Data From Fitness Trackers.JMIR formative research · 2024Article
- Associations of Physical Activity and Heart Rate Variability from a Two-Week ECG Monitor with Cognitive Function and Dementia: The ARIC Neurocognitive Study.Sensors (Basel, Switzerland) · 2024Article
- Embodimetrics: A Principal Component Analysis Study of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters.Sensors (Basel, Switzerland) · 2024Article
- Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment.BMC medicine · 2024Article
- Heart Rate Variability and Cognition: A Narrative Systematic Review of Longitudinal Studies.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neurodegenerative diseases, which frequently present with neuropsychiatric symptoms related to prefrontal cortical dysfunction, can alter the integrity of the neural networks involved in central autonomic nervous system regulation, which is proposed to be indexed by heart rate variability (HRV). We systematically reviewed the characteristics, methodology and outcomes of 27 studies of HRV in relation to measures of cognition and behavior in neurodegenerative conditions, and assessed the strength of this relationship, cross-sectionally, across 18 studies. A significant, moderate effect was observed (r = 0.25), such that higher HRV was related to better cognitive and behavioral scores, which was not influenced by mean age or cognitive status. There was no evidence of small-study effects but we could not rule out publication bias, and other factors may have contributed to heterogeneity between studies. Our findings support the proposal that HRV may be a marker of self-regulatory processes in neurodegenerative conditions, and further research on this association is needed in relation to neuropsychiatric symptoms and alongside neuroimaging methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.