ArticleGastroenterology2022
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
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In one paragraph
Article in Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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147citing papers in PubMed, 2 pooled it
12.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
147 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Cancer-associated fibroblasts, and clinicopathological characteristics and prognosis of gastric cancer: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Decoding osteosarcoma pathogenesis: the pivotal influence of mEpigenetics · 2026Review
- Identification of cancer-associated fibroblast biomarkers in cutaneous squamous cell carcinoma.Oncology letters · 2026Article
- Vascular plasticity in the gastric cancer environment: mechanisms, prognostic significance, and concepts of therapeutic interventions.Cancer metastasis reviews · 2026Review
- Cellular crosstalk of fibroblast-myofibroblast transition in intestinal homeostasis and disease.Biomarker research · 2026Review
- Article
- Unraveling the roles of fibroblast activation protein‑positive cancer‑associated fibroblasts in cancer: From mechanisms to therapy (Review).International journal of oncology · 2026Review
- Spatium: A Protein Language Foundation Model for Spatial Proteomics.bioRxiv : the preprint server for biology · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- The exosomal miRNA/FOXN3 axis empowers fibroblasts with tumor-promoting functions via enhanced migration and altered secretome.Journal of nanobiotechnology · 2026Article
- Bidirectional crosstalk between cancer-associated fibroblasts and tumor immunity: shaping the microenvironment and response to immune checkpoint therapy.Experimental hematology & oncology · 2026Review
- The value of extracellular volume based on spectral CT in lymph node metastasis, perineural invasion, and lymphovascular invasion of colon cancer.Abdominal radiology (New York) · 2026Article
- Fibroblast-derived HSD11B1 deficiency drives lung cancer in never-smokers through steroid metabolic imbalance.NPJ precision oncology · 2026Article
- Article
- STK25 inhibits cancer-associated fibroblast activation to overcome cetuximab resistance in colorectal cancer.Clinical and translational medicine · 2026Article
- Transgelin Expression in Activated Cancer-Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression.Cancer medicine · 2026Article
- Cancer-Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The research advances of crosstalk between cancer-associated fibroblasts and tumor cells using co-culture organoids.Cell death & disease · 2026Review
- Notch3 regulates pericyte phenotypic plasticity in colorectal cancer.Communications biology · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
37 authors at 12 institutions in 5 countries.
Hiroki KobayashiAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Krystyna A GieniecAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Tamsin R M LannaganAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Tongtong WangAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Naoya AsaiDepartment of Molecular Pathology, Graduate School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
Yasuyuki MizutaniDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Tadashi IidaDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Ryota AndoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Elaine M ThomasAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Akihiro SakaiDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Nobumi SuzukiAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Mari IchinoseAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Josephine A WrightSouth Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Laura VrbanacAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Jia Q NgAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Jarrad GoyneAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Georgette RadfordAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Matthew J LawrenceColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Tarik SammourAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; Colorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sonja KlebeDepartment of Anatomical Pathology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, Australia.
Alice E ShinPathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Samuel AsfahaDepartment of Medicine, University of Western Ontario, London, Ontario, Canada.
Mark L BettingtonEnvoi Specialist Pathologists, Kelvin Grove, Queensland, Australia; Faculty of Medicine, University of Queensland, Herston, Queensland, Australia; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Florian RiederDepartment of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Nicholas ArpaiaDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Tal DaninoHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA; Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Lisa M ButlerAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Alastair D BurtAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Simon J LeedhamIntestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, United Kingdom.
Anil K RustgiHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
Siddhartha MukherjeeDepartment of Medicine and Irving Cancer Research Center, Columbia University, New York, New York, USA.
Masahide TakahashiDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Aichi, Japan.
Timothy C WangDepartment of Medicine and Irving Cancer Research Center, Columbia University, New York, New York, USA.
Atsushi EnomotoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address: enomoto@iar.nagoya-u.ac.jp.
Susan L WoodsAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia. Electronic address: susan.woods@adelaide.edu.au.
Daniel L WorthleySouth Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; GastroIntestinal Endoscopy, Lutwyche, Queensland, Australia. Electronic address: dan@colonoscopyclinic.com.au.
South Australian Health and Medical Research Institute · AUColumbia University Irving Medical Center · USNagoya University · JPFujita Health University · JPRoyal Adelaide Hospital · AUWestern University · CACentre for Human Genetics · GBCleveland Clinic · USFlinders Medical Centre · AUThe University of Adelaide · AUThe University of Queensland · AUThe University of Tokyo · JP
Funding
The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2MThe LIN28b-Let7-IMP1 axis in colonic epithelial biologyR01DK056645 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2000 to 2021
$6.8MUnderstanding stem cell heterogeneity and niche function in intestinal regeneration after irradiationU01DK103155 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUHA, CHANDAN, WANG, TIMOTHY CRAGIN · 2014 to 2023
$4.4MCreeping fat and Crohn's disease associated stricturesR01DK123233 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI RIEDER, FLORIAN · 2020 to 2024
$1.9MMicrobiota in Intestinal FibrosisK08DK110415 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI RIEDER, FLORIAN · 2016 to 2020
$767kMedical Research Council MR/N005872/1NCI NIH HHS R35 CA210088NIDDK NIH HHS K08 DK110415NIDDK NIH HHS R01 DK056645NIDDK NIH HHS R01 DK123233NIDDK NIH HHS U01 DK103155Wellcome Trust 206314/Z/17/Z
Abstract
BACKGROUND &
aimsCancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeutically target these cells. Here, we aimed to identify the origins and contribution of colorectal CAFs associated with poor prognosis.
methodsTo elucidate CAF origins, we used a colitis-associated CRC mouse model in 5 different fate-mapping mouse lines with 5-bromodeoxyuridine dosing. RNA sequencing of fluorescence-activated cell sorting-purified CRC CAFs was performed to identify a potential therapeutic target in CAFs. To examine the prognostic significance of the stromal target, CRC patient RNA sequencing data and tissue microarray were used. CRC organoids were injected into the colons of knockout mice to assess the mechanism by which the stromal gene contributes to colorectal tumorigenesis.
resultsOur lineage-tracing studies revealed that in CRC, many ACTA2
conclusionsIn colorectal carcinogenesis, pericryptal Lepr-lineage cells proliferate to generate MCAM
Indexed as
Cell LineageActinsAdultAgedAged, 80 and overAnimalsCancer-Associated FibroblastsCarcinogenesisCD146 AntigenCell DifferentiationCell ProliferationColorectal NeoplasmsDisease Models, AnimalFemaleHumansIntestinal MucosaACTA2 protein, humanActa2 protein, mouseActinsCD146 AntigenKi-67 AntigenLEPR protein, humanleptin receptor, mouseMCAM protein, humanMcam protein, mouseReceptors, LeptinAlpha-Smooth Muscle Actin (αSMA)CD146Colorectal CancerTumor Microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.