Evidence map›Paper›PMID 34883117›Full record

ArticleJournal of molecular biology2022

Molecular Determinants in tRNA D-arm Required for Inhibition of HIV-1 Gag Membrane Binding.

Christopher Sumner, Osamu Kotani, Shuohui Liu, Karin Musier-Forsyth, Hironori Sato, Akira Ono

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. The "basics" of HIV-1 assembly.PLoS pathogens · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Christopher SumnerDept. of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States.
Osamu KotaniCenter for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan.
Shuohui LiuDept. of Chemistry and Biochemistry, Center for Retrovirus Research, and Center for RNA Biology, The Ohio State University, Columbus, OH, United States.
Karin Musier-ForsythDept. of Chemistry and Biochemistry, Center for Retrovirus Research, and Center for RNA Biology, The Ohio State University, Columbus, OH, United States.
Hironori SatoCenter for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan.
Akira OnoDept. of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States. Electronic address: akiraono@umich.edu.
National Institute of Infectious Diseases · JPThe Ohio State University · USUniversity of Michigan–Ann Arbor · US

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Mechanisms that determine subcellular sites of HIV-1 assemblyR37AI071727 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Akira Ono · 2017 to 2026
$6.2M
RNA binding and packaging by retroviral Gag proteinsR01AI153216 · NIAID · OHIO STATE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M · 2020 to 2025
$4.9M
The Molecular Mechanisms Contributing to the Specific Localization of HIV-1 Gag to the Plasma MembraneF31AI134287 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUMNER, CHRISTOPHER AARON · 2018 to 2019
$73k
NIAID NIH HHS F31 AI134287NIAID NIH HHS R01 AI153216NIAID NIH HHS R37 AI071727NIAID NIH HHS T32 AI007528
6 · The paper itself

Abstract

Plasma-membrane-specific localization of Gag, an essential step in HIV-1 particle assembly, is regulated by the interaction of the Gag MA domain with PI(4,5)P

Indexed as

AnticodonBinding SitesCell Membranegag Gene Products, Human Immunodeficiency VirusHIV-1HumansMolecular Docking SimulationPhosphatidylinositol 4,5-DiphosphateProtein Interaction Domains and MotifsRNA, TransferRNA, ViralVirus AssemblyAnticodongag Gene Products, Human Immunodeficiency VirusPhosphatidylinositol 4,5-DiphosphateRNA, TransferRNA, Viralacidic phospholipidhighly basic regionlipid-protein interactiontRNA–protein interactionvirus assembly

Identifiers

PMID34883117
PMCPMC8752508
OpenAlexW4200549103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.