Evidence map›Paper›PMID 34883017›Full record

ArticleThe journal of physical chemistry. B2021

A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue.

Felix Gorka, Sam Daly, Colin M Pearson, Edita Bulovaite, Yu P Zhang, Anoushka Handa, Seth G N Grant, Thomas N Snaddon, Lisa-Maria Needham, Steven F Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Felix GorkaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Sam DalyYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Colin M PearsonDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Edita BulovaiteGenes to Cognition Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, U.K.
Yu P ZhangYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Anoushka HandaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Seth G N GrantGenes to Cognition Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, U.K.
Thomas N SnaddonDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-1119-0332
Lisa-Maria NeedhamYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0002-8139-5862
Steven F LeeYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0003-4492-5139
University of Cambridge · GBIndiana University Bloomington · USMRC Centre for Regenerative Medicine · GBPhilipps University of Marburg · DEUniversity of Wisconsin–Madison · US

Funding

Asymmetric Chemical Synthesis Methods via Cooperative CatalysisR01GM121573 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI SNADDON, THOMAS NEIL · 2016 to 2020
$1.5M
European Research Council 695568NIGMS NIH HHS R01 GM121573Wellcome Trust 202932
6 · The paper itself

Abstract

Optical imaging of protein aggregates in living and post-mortem tissue can often be impeded by unwanted fluorescence, prompting the need for novel methods to extract meaningful signal in complex biological environments. Historically, benzothiazolium derivatives, prominently Thioflavin T, have been the state-of-the-art fluorescent probes for amyloid aggregates, but their optical, structural, and binding properties typically limit them to

Indexed as

alpha-SynucleinAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsBenzothiazolesFluorescent DyesOptical ImagingSpectrometry, Fluorescencealpha-SynucleinAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsBenzothiazolesFluorescent Dyes

Identifiers

PMID34883017
PMCPMC7615715
OpenAlexW4200202434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.