ArticlePloS one2021
Impact of sleep on the microbiome of oral biofilms.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Oral microbiota in obstructive sleep apnea patients: a systematic review.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- The impact of organ transplantation on changes in the oral microbiome, particularly on bacteria causing periodontal inflammation - narrative review.Frontiers in cellular and infection microbiology · 2026Review
- Association between tooth brushing habits and incident disability in community-dwelling older adults: a prospective cohort study.Environmental health and preventive medicine · 2026Article
- A Tri-Source Microbiome Dataset from Human Sleep Environments: Saliva, Pillow Dust, and Bedroom Air.Lifestyle genomics · 2026Article
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Association between oral microbiome and sleep disorders in U.S. adults: analysis of NHANES database 2009-2012.BMC oral health · 2025Article
- Association Between Lactoferrin Gene Polymorphism and Dental Caries in Saudi Children: A Case-Control Study.Cureus · 2025Article
- Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development.Cancers · 2025Review
- Evaluation of early bacterial adhesion on CAD/CAM dental materials: an in situ study.Odontology · 2025Article
- Positive Role of Saliva in the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Prevalence of dental caries and influence factors among students in Beijing: A cross-sectional study.PloS one · 2025Article
- Sleep and periodontal health.Periodontology 2000 · 2024Review
- The Relationship between Sleep, Chronotype, and Dental Caries-A Narrative Review.Clocks & sleep · 2023Review
- Insights into oral microbiome and colorectal cancer - on the way of searching new perspectives.Frontiers in cellular and infection microbiology · 2023Review
- Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans.Molecular psychiatry · 2022Article
- Impact of facemasks on the mouth as an emerging dental concern: A survey among residents of Karachi.Clinical epidemiology and global healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysbiosis of the oral microbiome is associated with diseases such as periodontitis and dental caries. Because the bacterial counts in saliva increase markedly during sleep, it is broadly accepted that the mouth should be cleaned before sleep to help prevent these diseases. However, this practice does not consider oral biofilms, including the dental biofilm. This study aimed to investigate sleep-related changes in the microbiome of oral biofilms by using 16S rRNA gene sequence analysis. Two experimental schedules-post-sleep and pre-sleep biofilm collection-were applied to 10 healthy subjects. Subjects had their teeth and oral mucosa professionally cleaned 7 days and 24 h before sample collection. Samples were collected from several locations in the oral cavity: the buccal mucosa, hard palate, tongue dorsum, gingival mucosa, tooth surface, and saliva. Prevotella and Corynebacterium had higher relative abundance on awakening than before sleep in all locations of the oral cavity, whereas fluctuations in Rothia levels differed depending on location. The microbiome in different locations in the oral cavity is affected by sleep, and changes in the microbiome composition depend on characteristics of the surfaces on which oral biofilms form.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.