ReviewPLoS neglected tropical diseases2021
Experimental human hookworm infection: a narrative historical review.
Review in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Closing the gap on gapeworm: experimental infection of Mammomonogamus ierei in domestic cats.Parasites & vectors · 2026Article
- Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody.Nature communications · 2026Article
- Advances in vaccine development through the controlled human infection models for hookworm and schistosomiasis.PLoS neglected tropical diseases · 2026Review
- Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement.Nutrition & metabolism · 2025Review
- Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report.Journal of medical case reports · 2025Article
- Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates.PLoS neglected tropical diseases · 2025Article
- Parasites and plantations: Disease, environment and society in efforts to induce extinction of hookworm in Jamaica, 1919-1936.Cambridge prisms. Extinction · 2025Article
- Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.Nature communications · 2024Article
- Is strongyloidiasis a zoonosis from dogs?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Clinical and laboratory findings of hookworms (Brazilian journal of veterinary medicine · 2024Article
- Botanicals against some important nematodal diseases: Ascariasis and hookworm infections.Saudi journal of biological sciences · 2023Review
- An efficient method for viable cryopreservation and recovery of hookworms and other gastrointestinal nematodes in the laboratory.International journal for parasitology · 2023Article
- Inhibition Effects ofPathogens (Basel, Switzerland) · 2022Article
- Comparison of coproprevalence and seroprevalence to guide decision-making in national soil-transmitted helminthiasis control programs: Ethiopia as a case study.PLoS neglected tropical diseases · 2022Article
- The production of Necator americanus larvae for use in experimental human infection.Parasites & vectors · 2022Article
- Therapeutic and Diagnostic Innovation for Parasitology: Grand Challenges.Frontiers in parasitology · 2022Article
- A case of severe hookworm infection.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- Effects of helminths on the human immune response and the microbiome.Mucosal immunology · 2022Review
- Organoids as tools to investigate gastrointestinal nematode development and host interactions.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1896, a serendipitous laboratory accident led to the understanding that hookworms propagate infection by penetrating skin, a theory that was then confirmed with the first experimental human infection, reported in 1901. Experimental human infections undertaken in the 20th century enabled understanding of the natural history of infection and the immune response. More recently, experimental hookworm infection has been performed to investigate the immunomodulatory potential of hookworm infection and for the evaluation of hookworm vaccines and chemotherapeutic interventions. Experimental human hookworm infection has been proven to be safe, with no deaths observed in over 500 participants (although early reports predate systematic adverse event reporting) and no serious adverse events described in over 200 participants enrolled in contemporary clinical trials. While experimental human hookworm infection holds significant promise, as both a challenge model for testing anti-hookworm therapies and for treating various diseases of modernity, there are many challenges that present. These challenges include preparation and storage of larvae, which has not significantly changed since Harada and Mori first described their coproculture method in 1955. In vitro methods of hookworm larval culture, storage, and the development of meaningful potency or release assays are required. Surrogate markers of intestinal infection intensity are required because faecal egg counts or hookworm faecal DNA intensity lack the fidelity required for exploration of hookworm infection as a vaccine/drug testing platform or as a regulated therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.