Evidence map›Paper›PMID 34882524›Full record

ArticleRNA biology2021

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

Raquel Mesquita-Ribeiro, Rafael Sebastián Fort, Alex Rathbone, Joaquina Farias, Cristiano Lucci, Victoria James, Jose Sotelo-Silveira, Maria Ana Duhagon, Federico Dajas-Bailador

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Emerging roles of transfer RNA fragments in the CNS.Brain : a journal of neurology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. RNA in axons, dendrites, synapses and beyond.Frontiers in molecular neuroscience · 2024
    Review
  12. The Expression Pattern of tRNA-Derived Small RNAs in AdultInternational journal of molecular sciences · 2023
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Raquel Mesquita-RibeiroSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Rafael Sebastián FortLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Alex RathboneSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Joaquina FariasDepartamento de Genómica, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Cristiano LucciSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Victoria JamesSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Jose Sotelo-SilveiraDepartamento de Genómica, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Maria Ana DuhagonLaboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Federico Dajas-BailadorSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-2212-1482
University of Nottingham · GBInstituto de Investigaciones Biológicas Clemente Estable · UYUniversidad de la República de Uruguay · UY

Funding

Wellcome Trust
6 · The paper itself

Abstract

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology, the identity and regulatory capacity of other small non-coding RNAs (sncRNAs) in neuronal models and local subdomains has been largely unexplored.We identified a highly complex and differentially localized content of sncRNAs in axons and EVs during early neuronal development of cortical primary neurons and in adult axons

Indexed as

Cell CommunicationAxonsBiological TransportCell FractionationComputational BiologyExtracellular VesiclesHigh-Throughput Nucleotide SequencingHumansMolecular Sequence AnnotationNeuronal OutgrowthNeuronsNucleic Acid ConformationRNA, Small UntranslatedRNA, TransferSubcellular FractionsRNA, Small UntranslatedRNA, Transferaxonextracellular vesiclesmiRNAsNeuronssncRNAstRNA-derived fragments

Identifiers

PMID34882524
PMCPMC8782166
OpenAlexW3214631367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.