ArticleScience (New York, N.Y.)2021
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
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45 citing papers in PubMed.
- Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.Cell death and differentiation · 2026Article
- Phosphatidylinositol diphosphate binding by ESCRT-III filaments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells.Journal of advanced research · 2026Article
- Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration.Scientific reports · 2026Article
- ESCRT-III function in membrane fission and repair.Nature reviews. Molecular cell biology · 2026Review
- Article
- Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.Progress in retinal and eye research · 2026Review
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- PIK3C2A-Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect.Clinical genetics · 2025Article
- SHIP2-PLK1 crosstalk promotes sensitivity to dual inhibition in esophageal squamous cell carcinoma.Molecular cancer · 2025Article
- Review
- Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy.Apoptosis : an international journal on programmed cell death · 2025Review
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- A non-canonical activation of the host's ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani.PLoS pathogens · 2025Article
- Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evidence of early genomic selection in Holstein Friesian across African and European ecosystems.BMC genomics · 2025Article
- From Bench to Bedside: Translational Approaches to Cardiotoxicity in Breast Cancer, Lung Cancer, and Lymphoma Therapies.Cancers · 2025Review
- Reply to: Do actin isoforms have unique functionalities at the protein level?Nature communications · 2025Article
- PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.The Journal of experimental medicine · 2025Article
- Advances in ocular aging: combining deep learning, imaging, and liquid biopsy biomarkers.Frontiers in medicine · 2025Review
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Authors and funding
32 authors.
Federico GulluniDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0001-7706-1635
Lorenzo PreverDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0001-5244-9211
Huayi LiDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
Petra KrafcikovaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha, Czech Republic.ORCID 0000-0002-3363-2499
Ilaria CorradoDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0003-0151-6247
Wen-Ting LoLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0001-7904-6834
Jean Piero MargariaDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0002-2435-7499
Anlu ChenDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Maria Chiara De SantisDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0003-2785-0665
Sophie J CnuddeDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0003-3121-2471
Joseph FogertyDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
Alex YuanDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0000-0003-0191-8035
Alberto MassarottiDipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.ORCID 0000-0001-9306-8845
Nasrin Torabi SarijaloDepartment of Nephrology and Hypertension, Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany.
Oscar VadasSection des Sciences Pharmaceutiques, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0003-3511-6479
Roger L WilliamsMedical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.ORCID 0000-0001-7754-4207
Marcus ThelenInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.ORCID 0000-0002-3443-1605
David R PowellPharmaceutical Biology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA.ORCID 0000-0001-8072-388X
Markus SchuelerDivision of Nephrology and Internal Intensive Care Medicine, Charite University, Berlin, Germany.
Michael S WiesenerDepartment of Nephrology and Hypertension, Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany.
Tamas BallaSection on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
Hagit N BarisDivision of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.ORCID 0000-0003-4065-7560
Dov TiosanoDivision of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.
Brian M McDermottDepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Brian D PerkinsDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0000-0002-9348-6542
Alessandra GhigoDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0002-1193-5296
Miriam MartiniDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0002-4262-946X
Volker HauckeLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0003-3119-6993
Evzen BouraInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha, Czech Republic.ORCID 0000-0002-9652-4065
Giorgio Roberto MerloDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
David A BuchnerDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-3920-4871
Emilio HirschDepartment of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0002-9073-6024
Funding
RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7MCilia Assembly and Transport in the Vertebrate RetinaR01EY017037 · NEI · TEXAS A&M UNIVERSITY · PI PERKINS, BRIAN D · 2006 to 2021
$5.5MRole of adipocyte gene expression regulation by Zfp407 in adipocyte biology and metabolic diseaseR01DK119305 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BUCHNER, DAVID A · 2019 to 2023
$2.0MStimulating Retina Regeneration from Muller Cells in Progressive Retinal DegenerationsR01EY030574 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI PERKINS, BRIAN D · 2020 to 2022
$1.6MMedical Research Council MC_U105184308NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY017037NEI NIH HHS R01 EY030574NIDDK NIH HHS R01 DK119305
Abstract
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines the cleavage site. Alteration of ESCRT function can lead to cataract, but the underlying mechanism and its relation to cytokinesis are unclear. We found a lens-specific cytokinetic process that required PI3K-C2α (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2α), its lipid product PI(3,4)P
Indexed as
Cellular SenescenceCytokinesisAging, PrematureAnimalsBiological EvolutionCalcium-Binding ProteinsCataractCell Cycle ProteinsCell LineEndosomal Sorting Complexes Required for TransportHumansLens, CrystallineMiceMutationPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphateCalcium-Binding ProteinsCell Cycle ProteinsCHMP4B protein, humanEndosomal Sorting Complexes Required for TransportPDCD6IP protein, humanPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsphosphoinositide-3,4-bisphosphatePIK3C2A protein, humanPik3c2a protein, mouseTubulinVPS36 protein, humanZebrafish Proteins
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