ReviewScience (New York, N.Y.)2021
Early-life imprinting of unconventional T cells and tissue homeostasis.
Review in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- UcTCRp: a TCRβ-based framework for identifying and profiling MAIT- and iNKT-associated repertoire signals.Briefings in bioinformatics · 2026Article
- Single-cell landscape of human liver sinusoidal γδ T cells in the context of latent human cytomegalovirus infection.Nature communications · 2026Article
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Review
- Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.Science (New York, N.Y.) · 2026Article
- Natural Killer T Cell Function in Lymphoma Patients.Biomolecules · 2026Article
- Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.Nature communications · 2026Article
- Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases.Acta pharmaceutica Sinica. B · 2026Review
- Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.Cell · 2026Review
- Revisiting T cells: Innate actions and emerging links to innate memory response.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood.The Journal of experimental medicine · 2026Article
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
- T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions.Frontiers in microbiology · 2026Review
- Immunological and molecular biomarkers in skin allergy therapy: monitoring inflammation, barrier function, and treatment response.Postepy dermatologii i alergologii · 2026Review
- Multifaceted mechanisms of unconventional T cells in ischemia-reperfusion injury.Frontiers in immunology · 2026Review
- Microbiota-driven epigenetic programming of local immunity.Frontiers in immunology · 2026Review
- MAIT Cells Maintain Intestinal Homeostasis Through IL-22 in an Experimental Colitis.Journal of inflammation research · 2026Article
- Anti-Inflammatory Properties of Ripe and Unripe Papaya Pectin in a Neonatal Human Stem Cell-Derived Ileum Model.Molecular nutrition & food research · 2026Article
- Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Unconventional T cells—including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and defined subsets of γδ T cells—are restricted by monomorphic major histocompatibility complex class Ib (MHC-Ib) molecules and seed tissues during development. Early-life instructive signals, including those derived from the microbiota, establish homeostatic set points for unconventional T cells, a phenomenon that has lifelong consequences for the regulation of tissue immunity, inflammation, and repair. Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.