ArticleeLife2021
Bidirectional synaptic plasticity rapidly modifies hippocampal representations.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 156 citations in OpenAlex.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Striatal endocannabinoids drive one-shot learning.Nature neuroscience · 2026Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging.iScience · 2026Article
- Distinct types of dendritic CaScience advances · 2026Article
- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- Population sparseness determines strength of Hebbian plasticity for maximal memory lifetime in associative networks.PLoS computational biology · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned.bioRxiv : the preprint server for biology · 2026Article
- Article
- Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input.Nature communications · 2026Article
- Cellular and subcellular specialization enables biology-constrained deep learning.Cell reports · 2026Article
- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Learning-dependent feedback by OLM interneurons shapes CA1 representations.bioRxiv : the preprint server for biology · 2026Article
- Review
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- Fast dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior.bioRxiv : the preprint server for biology · 2026Article
- Neural sampling from cognitive maps enables goal-directed imagination and planning.Nature machine intelligence · 2026Article
- Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic calcium spikes, or plateau potentials, has been reported to underlie place field formation in rodent hippocampal CA1 neurons. Here, we found that this behavioral timescale synaptic plasticity (BTSP) can also reshape existing place fields via bidirectional synaptic weight changes that depend on the temporal proximity of plateau potentials to pre-existing place fields. When evoked near an existing place field, plateau potentials induced less synaptic potentiation and more depression, suggesting BTSP might depend inversely on postsynaptic activation. However, manipulations of place cell membrane potential and computational modeling indicated that this anti-correlation actually results from a dependence on current synaptic weight such that weak inputs potentiate and strong inputs depress. A network model implementing this bidirectional synaptic learning rule suggested that BTSP enables population activity, rather than pairwise neuronal correlations, to drive neural adaptations to experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.