Evidence map›Paper›PMID 34881780›Full record

ReviewEmerging topics in life sciences2021

Artificial intelligence unifies knowledge and actions in drug repositioning.

Zheng Yin, Stephen T C Wong

Abstract readReview
In one paragraph

Review in Emerging topics in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zheng YinDepartment of Systems Medicine and Bioengineering, Houston Methodist Cancer Center and Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX 77030, U.S.A.ORCID 0000-0002-3547-0606
Stephen T C WongDepartment of Systems Medicine and Bioengineering, Houston Methodist Cancer Center and Ting Tsung & Wei Fong Chao Center for BRAIN, Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX 77030, U.S.A.

Funding

Systematic modeling and prediction of cell-type-specific and spatiotemporal crosstalk pathways in Alzheimer's DiseaseR01AG071496 · NIA · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KIM, DOO YEON, WONG, STEPHEN TC · 2021 to 2025
$4.0M
Systematic Alzheimer's disease drug repositioning (SMART) based on bioinformatics-guided phenotype screening and image-omicsR01AG057635 · NIA · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WONG, STEPHEN TC · 2018 to 2022
$3.5M
Early and late-life metal exposures and Alzheimer's diseaseR01ES024165 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI WEISSKOPF, MARC G · 2014 to 2019
$3.3M
NIA NIH HHS R01 AG057635NIA NIH HHS R01 AG071496NIEHS NIH HHS R01 ES024165
6 · The paper itself

Abstract

Drug repositioning aims to reuse existing drugs, shelved drugs, or drug candidates that failed clinical trials for other medical indications. Its attraction is sprung from the reduction in risk associated with safety testing of new medications and the time to get a known drug into the clinics. Artificial Intelligence (AI) has been recently pursued to speed up drug repositioning and discovery. The essence of AI in drug repositioning is to unify the knowledge and actions, i.e. incorporating real-world and experimental data to map out the best way forward to identify effective therapeutics against a disease. In this review, we share positive expectations for the evolution of AI and drug repositioning and summarize the role of AI in several methods of drug repositioning.

Indexed as

Artificial IntelligenceDrug Repositioningartificial intelligencecomputational biologydeep learningdrug repositioningsystems medicine

Identifiers

PMID34881780
PMCPMC8923082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.