ArticleJournal of the American Chemical Society2021
Ion Pathways in Biomineralization: Perspectives on Uptake, Transport, and Deposition of Calcium, Carbonate, and Phosphate.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 104 citations in OpenAlex.
- Article
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- Calcium trafficking in the mussel Mytilus galloprovincialis suggests conserved biomineralization pathways.Communications biology · 2026Article
- Biomimetic Deposition of Zn-Doped Calcium Phosphate Coatings on Surface-Activated Ti6Al4V for Multifunctional Implant Interfaces.Journal of functional biomaterials · 2026Article
- Cell-Mediated Mechanical Stability Enhancement of Biomimetic Collagen-Alginate Hydrogels: A Mechanistic Study on the Two-Dimensional Extracellular Matrix-Cell Interaction.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Proton channels govern vesicular carbonate chemistry in mineralizing cells of a marine calcifier.Nature communications · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Insights on the intracellular trafficking of calcifying medium in a reef-building coral.Communications biology · 2025Article
- Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Underlying charge-transfer mechanism of visible light emission in guanine crystals.Communications chemistry · 2025Article
- The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.Bioelectronic medicine · 2025Review
- Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented CaMaterials today. Bio · 2025Article
- Non-Stoichiometric Amorphous Calcium Carbonate Forms in Macromolecular Condensates via Interphase Diffusion.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Salt Metathesis: An Ultimate Click Reaction.Precision chemistry · 2025Article
- Biomaterials-mediated biomineralization for tumor blockade therapy.Nanomedicine (London, England) · 2025Review
- A polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior.Chemical science · 2024Article
- Biocalcification in porcelaneous foraminifera.eLife · 2024Article
- Bioinspired Bone Seed 3D-Printed Scaffold via Trapping Black Phosphorus Nanosheet for Bone Regeneration.Small science · 2024Article
- Structure of biomimetic casein micelles: Critical tests of the hydrophobic colloid and multivalent-binding models using recombinant deuterated and phosphorylated β-casein.Journal of structural biology: X · 2024Article
- Anisotropic Liesegang pattern for the nonlinear elastic biomineral-hydrogel complex.Science advances · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minerals are formed by organisms in all of the kingdoms of life. Mineral formation pathways all involve uptake of ions from the environment, transport of ions by cells, sometimes temporary storage, and ultimately deposition in or outside of the cells. Even though the details of how all this is achieved vary enormously, all pathways need to respect both the chemical limitations of ion manipulation, as well as the many "housekeeping" roles of ions in cell functioning. Here we provide a chemical perspective on the biological pathways of biomineralization. Our approach is to compare and contrast the ion pathways involving calcium, phosphate, and carbonate in three very different organisms: the enormously abundant unicellular marine coccolithophores, the well investigated sea urchin larval model for single crystal formation, and the complex pathways used by vertebrates to form their bones. The comparison highlights both common and unique processes. Significantly, phosphate is involved in regulating calcium carbonate deposition and carbonate is involved in regulating calcium phosphate deposition. One often overlooked commonality is that, from uptake to deposition, the solutions involved are usually supersaturated. This therefore requires not only avoiding mineral deposition where it is not needed but also exploiting this saturated state to produce unstable mineral precursors that can be conveniently stored, redissolved, and manipulated into diverse shapes and upon deposition transformed into more ordered and hence often functional final deposits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.