ArticleChembiochem : a European journal of chemical biology2022
Prebiotic Membranes and Micelles Do Not Inhibit Peptide Formation During Dehydration.
Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Preferential survival of prebiotic metallopeptides in the presence of ultraviolet light.Chemical science · 2025Article
- Model Atmospheric Aerosols Convert to Vesicles upon Entry into Aqueous Solution.ACS earth & space chemistry · 2023Article
- Prebiotic Environments with MgACS earth & space chemistry · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Cycles of dehydration and rehydration could have enabled formation of peptides and RNA in otherwise unfavorable conditions on the early Earth. Development of the first protocells would have hinged upon colocalization of these biopolymers with fatty acid membranes. Using atomic force microscopy, we find that a prebiotic fatty acid (decanoic acid) forms stacks of membranes after dehydration. Using LC-MS-MS (liquid chromatography-tandem mass spectrometry) with isotope internal standards, we measure the rate of formation of serine dipeptides. We find that dipeptides form during dehydration at moderate temperatures (55 °C) at least as fast in the presence of decanoic acid membranes as in the absence of membranes. Our results are consistent with the hypothesis that protocells could have formed within evaporating environments on the early Earth.
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