Evidence map›Paper›PMID 34881367›Full record

ArticleCritical care explorations2021

A Tale of Two Waves: Changes in the Use of Noninvasive Ventilation and Prone Positioning in Critical Care Management of Coronavirus Disease 2019.

Alexander J Parker, Monalisa Mishra, Pooja Tiwary, Mike Sharman, Manu Priya-Sharma, Alastair Duncan, Mohan Shanmugam, Kailash Bhatia, Catherine Fullwood, Andrew D Martin and 1 more

Abstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander J ParkerAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Monalisa MishraAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Pooja TiwaryAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Mike SharmanAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Manu Priya-SharmaDepartment of Anaesthesia and Peri-operative Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Alastair DuncanDepartment of Anaesthesia and Peri-operative Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Mohan ShanmugamDepartment of Anaesthesia and Peri-operative Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Kailash BhatiaDepartment of Anaesthesia and Peri-operative Medicine, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Catherine FullwoodDepartment of Statistics, Research & Innovation, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Andrew D MartinAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Anthony WilsonAdult Critical Care Department, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New treatments and increased experience are changing the management of hospitalized coronavirus disease 2019 patients but the impact on ICU management is unclear.

objectivesTo examine characteristics, ventilatory management, and outcomes of critically ill patients in two distinct waves of the pandemic. DESIGN SETTING AND

participantsObservational cohort study in an ICU in a single-center university-affiliated U.K. hospital. Two-hundred ten adults with coronavirus disease 2019 admitted to ICU between March 17, 2020, to May 31, 2020, and September 1, 2020, to December 10, 2020, with hourly data and 100% follow-up to ICU discharge. MAIN OUTCOMES AND MEASURES: Data were extracted from the electronic medical record for patient characteristics and clinical data. Patients were classified into distinct waves of the pandemic and assessed for differences between the two waves.

resultsThe duration of noninvasive ventilation/nasal high flow increased in wave 2 versus wave 1, both in self-ventilating patients (107 vs 72 hr; CONCLUSIONS AND RELEVANCE: Our data suggest that management of critically ill coronavirus disease 2019 patients is changing with more survivors avoiding invasive mechanical ventilation. Duration of noninvasive ventilation/nasal high flow use is increasing, which may be associated with worsening outcomes for individuals who require invasive mechanical ventilation. Among invasively ventilated patients, changes in the use of and response to prone positioning and increased length of stay following tracheostomy may imply that the care of these patients is becoming more challenging.

Indexed as

acute respiratory distress syndromecoronavirus disease 2019intensive careoutcomesproningventilation

Identifiers

PMID34881367
PMCPMC8647894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.