Evidence map›Paper›PMID 34881366›Full record

ArticleCritical care explorations2021

A Daily, Respiratory Therapist Assessment of Readiness to Liberate From Venovenous Extracorporeal Membrane Oxygenation in Patients With Acute Respiratory Distress Syndrome.

Elias H Pratt, Sarah Mausert, Michael D Wilson, Logan J Emerson, Neelima Navuluri, Aaron M Pulsipher, Amanda Brucker, Cynthia L Green, Desiree K Bonadonna, Benjamin S Bryner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elias H PrattDepartment of Medicine, Duke University Health System, Durham, NC.
Sarah MausertDepartment of Respiratory Care, Duke University Health System, Durham, NC.
Michael D WilsonDepartment of Respiratory Care, Duke University Health System, Durham, NC.
Logan J EmersonDepartment of Respiratory Care, Duke University Health System, Durham, NC.
Neelima NavuluriDepartment of Medicine, Duke University Health System, Durham, NC.
Aaron M PulsipherDepartment of Medicine, Duke University Health System, Durham, NC.
Amanda BruckerDepartment of Biostatistics and Bioinformatics, Duke University Health System, Durham, NC.
Cynthia L GreenDepartment of Biostatistics and Bioinformatics, Duke University Health System, Durham, NC.
Desiree K BonadonnaDepartment of Perfusion, Duke University Health System, Durham, NC.
Benjamin S BrynerDepartment of Surgery, Duke University Health System, Durham, NC.
Craig R RackleyDepartment of Medicine, Duke University Health System, Durham, NC.
Duke University Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the effect of implementing a protocol-directed strategy to determine when patients can be liberated from venovenous extracorporeal membrane oxygenation on extracorporeal membrane oxygenation duration, time to initiation of first sweep-off trial, duration of mechanical ventilation, ICU length of stay, hospital length of stay, and survival to hospital discharge.

designSingle-center retrospective before and after study.

settingThe medical ICU at an academic medical center. PATIENTS: One-hundred eighty patients with acute respiratory distress syndrome managed with venovenous extracorporeal membrane oxygenation at a single institution from 2013 to 2019.

interventionsIn 2016, our institution implemented a daily assessment of readiness for a trial off extracorporeal membrane oxygenation sweep gas ("sweep-off trial"). When patients met prespecified criteria, the respiratory therapist performed a sweep-off trial to determine readiness for discontinuation of venovenous extracorporeal membrane oxygenation. MEASUREMENTS AND MAIN

resultsSixty-seven patients were treated before implementation of the sweep-off trial protocol, and 113 patients were treated after implementation. Patients managed using the sweep-off trial protocol had a significantly shorter extracorporeal membrane oxygenation duration (5.5 d [3-11 d] vs 11 d [7-15.5 d];

conclusionsIn patients with acute respiratory distress syndrome managed with venovenous extracorporeal membrane oxygenation at our institution, implementation of a daily, respiratory therapist assessment of readiness for a sweep-off trial was associated with a shorter time to first sweep-off trial and shorter duration of extracorporeal membrane oxygenation. Among survivors, the postassessment group had a reduced duration of mechanical ventilation and ICU lengths of stay. There were no observed differences in hospital length of stay or inhospital mortality.

Indexed as

acute respiratory distress syndromeduration of treatmentextracorporeal membrane oxygenationhospital respiratory therapy departmentlength of stay

Identifiers

PMID34881366
PMCPMC8647875
OpenAlexW4200275380

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.