ArticlePorto biomedical journal
Protective effect of aqueous leaf extracts of
Article in Porto biomedical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Cardioprotective Potential ofCurrent pharmaceutical biotechnology · 2025Article
- Evaluation of the Hepatoprotective Properties of Traditional Formulations Based onAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Glycine protects against doxorubicin-induced heart toxicity in mice.Amino acids · 2023Article
- Restoration of plasma kidney and liver biomarkers in doxorubicin-treated Wistar rats by aqueous extracts ofBiotechnologia · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver is one of the organs affected by doxorubicin toxicity. Therefore, in this study, the potential protective role of aqueous leaf extracts of
methodsIn order to achieve this, their impact on hepatic biomarkers of oxidative stress, lipid and electrolytes' profile, and plasma biomarkers of liver functions/integrity were monitored in doxorubicin treated rats. The animals were treated with either metformin (250 mg/kg body weight orally for 14 days) or the extracts (50, 75, and 100 mg/kg orally for 14 days) and/or doxorubicin (15 mg/kg, intraperitoneal, 48 h before sacrifice).
resultsThe hepatic malondialdehyde, cholesterol, calcium, and sodium concentrations, and plasma activities of alanine and aspartate transaminases and alkaline phosphatase, as well as plasma albumin to globulin ratio of test control were significantly (
conclusionsPretreatment with the extracts and metformin prevented to varying degrees, doxorubicin-induced hepatic damage, as indicated by the attenuation of doxorubicin-induced adverse alterations in hepatic biomarkers of oxidative stress, lipid and electrolyte profiles, and plasma biomarkers of hepatic function/integrity, and keeping them at near-normal values.
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