Evidence map›Paper›PMID 34881290›Full record

ReviewFrontiers in molecular biosciences2021

Glutathione Transferases as Efficient Ketosteroid Isomerases.

Bengt Mannervik, Aram Ismail, Helena Lindström, Birgitta Sjödin, Nancy H Ing

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Unveiling the Role of GlutathioneACS pharmacology & translational science · 2026
    Review
  3. Article
  4. Bioactive Potential ofBioMed research international · 2025
    Article
  5. Article
  6. Structural Analysis of theBiomolecules · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. The Role of Glutathione in Selected Viral Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Bengt MannervikDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Aram IsmailDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Helena LindströmDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Birgitta SjödinDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Nancy H IngDepartment of Animal Science, Texas A&M AgriLife Research, Texas A&M University, College Station, TX, United States.
Stockholm University · SETexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to their well-established role in detoxication, glutathione transferases (GSTs) have other biological functions. We are focusing on the ketosteroid isomerase activity, which appears to contribute to steroid hormone biosynthesis in mammalian tissues. A highly efficient GST A3-3 is present in some, but not all, mammals. The alpha class enzyme GST A3-3 in humans and the horse shows the highest catalytic efficiency with k

Indexed as

alternative functionsandrostenedioneecdysteroidenzyme evolutionglutathioneketosteroid isomeraseprogesteronesteroid hormone

Identifiers

PMID34881290
PMCPMC8645602
OpenAlexW3214966814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.