Evidence map›Paper›PMID 34881273›Full record

ArticleFrontiers in medicine2021

Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis-A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative.

Mingyang Li, Yong Nie, Yi Zeng, Yuangang Wu, Yuan Liu, Limin Wu, Jiawen Xu, Bin Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mingyang LiDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Yong NieDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Yi ZengDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Yuangang WuDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Yuan LiuDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Limin WuDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Jiawen XuDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Bin ShenDepartment of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear. We found that bisphosphonate use did not increase sclerosis of subchondral bone in established KOA, perhaps resolving some concerns about bisphosphonate in patients with KOA.

Indexed as

bisphosphonateBVFsubchondral bone morphometryTb.NTb.SpTb.Th

Identifiers

PMID34881273
PMCPMC8647025
OpenAlexW3217389281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.