ArticlePulmonary circulation
Vascular remodeling of the small pulmonary arteries and measures of vascular pruning on computed tomography.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Quantification of chronic vascular remodeling in sickle cell disease.European radiology · 2026Article
- KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.Communications biology · 2026Article
- Pulmonary Vascular Remodeling in Smokers: A Systematic Review of Quantitative CT and Histologic Evidence.Cureus · 2026Review
- The vascular fingerprint of the lungs: why pulmonary vessel count matters in COPD.The European respiratory journal · 2026Article
- Sex-specific insights in atherosclerosis and pulmonary arterial hypertension: an overlooked comorbidity.Frontiers in cardiovascular medicine · 2026Review
- Predictive value of quantitative CT-derived emphysema heterogeneity for outcomes following bronchoscopic lung volume reduction.American journal of translational research · 2026Article
- Assessing pulmonary vascular remodeling in connective tissue disease-associated interstitial lung disease: a CT-based quantitative analysis.Quantitative imaging in medicine and surgery · 2025Article
- Automated volumetry of core and peel intrapulmonary vasculature on computed tomography angiography for non-invasive estimation of hemodynamics in patients with pulmonary hypertension (2022 updated hemodynamic definition).Cardiovascular diagnosis and therapy · 2024Article
- Quantitative assessment of pulmonary blood flow redistribution in the classification of group 1 and group 4 pulmonary hypertension.Quantitative imaging in medicine and surgery · 2024Article
- Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension.The Journal of experimental medicine · 2024Article
- Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study.American journal of respiratory and critical care medicine · 2024Article
- Imaging the Intersection of Parenchymal Abnormalities and Pulmonary Vascular Pathways.American journal of respiratory and critical care medicine · 2024Article
- Emerging multimodality imaging techniques for the pulmonary circulation.The European respiratory journal · 2024Review
- Higher small pulmonary artery and vein volume on computed tomography is associated with mortality in current and former smokers.EBioMedicine · 2024Article
- Sex-related differences in pulmonary vascular volume distribution.Pulmonary circulation · 2024Article
- Relative Loss of Small Pulmonary Vessels on Imaging and Risk of Recurrence of Resected Lung Adenocarcinoma.Annals of the American Thoracic Society · 2023Article
- CT imaging determinants of persistent hypoxemia in acute intermediate-risk pulmonary embolism.Journal of thrombosis and thrombolysis · 2023Article
- Emerging phenotypes of pulmonary hypertension associated with COPD: a field guide.Current opinion in pulmonary medicine · 2022Review
- Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.Circulation research · 2022Review
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
Pulmonary hypertension is characterized histologically by intimal and medial thickening in the small pulmonary arteries, eventually resulting in vascular "pruning." Computed tomography (CT)-based quantification of pruning is associated with clinical measures of pulmonary hypertension, but it is not established whether CT-based pruning correlates with histologic arterial remodeling. Our sample consisted of 138 patients who underwent resection for early-stage lung adenocarcinoma. From histologic sections, we identified small pulmonary arteries and measured the relative area comprising the intima and media (VWA%), with higher VWA% representing greater histologic remodeling. From pre-operative CTs, we used image analysis algorithms to calculate the small vessel volume fraction (BV5/TBV) as a CT-based indicator of pruning (lower BV5/TBV represents greater pruning). We investigated relationships of CT pruning and histologic remodeling using Pearson correlation, simple linear regression, and multivariable regression with adjustment for age, sex, height, weight, smoking status, and total pack-years. We also tested for effect modification by sex and smoking status. In primary models, more severe CT pruning was associated with greater histologic remodeling. The Pearson correlation coefficient between BV5/TBV and VWA% was -0.41, and in linear regression models, VWA% was 3.13% higher (95% CI: 1.95-4.31%, p < 0.0001) per standard deviation lower BV5/TBV. This association persisted after multivariable adjustment. We found no evidence that these relationships differed by sex or smoking status. Among individuals who underwent resection for lung adenocarcinoma, more severe CT-based vascular pruning was associated with greater histologic arterial remodeling. These findings suggest CT imaging may be a non-invasive indicator of pulmonary vascular pathology.
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