Evidence map›Paper›PMID 34880957›Full record

ArticleDisease markers2021

Tanshinone IIA Improves Ventricular Remodeling following Cardiac Infarction by Regulating miR-205-3p.

Peng Qiao, Jie Xu, Xueni Liu, Xuehan Li

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peng QiaoDepartment of Traditional Chinese Medicine, Yantaishan Hospital, Yantai, China.
Jie XuDepartment of Medical Security Center, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Xueni LiuCritical Care Medicine, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Xuehan LiDepartment of Geriatrics, Liaocheng People's Hospital, Liaocheng, China.ORCID https://orcid.org/0000-0003-2445-6486
Liaocheng People's Hospital · CNYantaishan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo illustrate the role of tanshinone IIA (TSN) in regulating cardiac structure and function following myocardial infarction (MI) and the involvement of miR-205-3p in TSN-induced antifibrosis effect on ventricular remodeling.

resultsCompared with the control group, miR-205-3p and TGF-

conclusionsThrough upregulating miR-205-3p and downregulating TGF-

Indexed as

Gene Expression RegulationAbietanesAnimalsCells, CulturedElectrocardiographyFemaleHumansMaleMicroRNAsMiddle AgedMyocardial InfarctionRatsTransforming Growth Factor beta1Ventricular Function, LeftVentricular RemodelingAbietanesMicroRNAsMIR205, humantanshinoneTGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID34880957
PMCPMC8648449
OpenAlexW3215478200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.