Evidence map›Paper›PMID 34880756›Full record

ReviewFrontiers in pharmacology2021

Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer.

Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A Genazzani

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The role of NADFrontiers in oncology · 2026
    Review
  3. Article
  4. Alterations in tryptophan metabolism andFrontiers in medicine · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giorgia ColomboDepartment of Pharmaceutical Sciences, Università Del Piemonte Orientale, Novara, Italy.
Edoardo Luigi Maria GelardiDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Federica Carolina BalestreroDepartment of Pharmaceutical Sciences, Università Del Piemonte Orientale, Novara, Italy.
Marianna MoroDepartment of Pharmaceutical Sciences, Università Del Piemonte Orientale, Novara, Italy.
Cristina TravelliDepartment of Drug Sciences, Università Degli Studi di Pavia, Pavia, Italy.
Armando A GenazzaniDepartment of Pharmaceutical Sciences, Università Del Piemonte Orientale, Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation.

Indexed as

ALDH = aldehyde dehydrogenaseCD38isocitrate dehydrogenase (IDH)NADNADPHNAMPT (nicotinamide phosphoribosyltransferase)PARPsirtuins

Identifiers

PMID34880756
PMCPMC8645963

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.